Method of binding recognizing substances to liposomes

Details Method of binding recognizing substances to liposomes Method of binding recognizing substances to liposomes

1994-10-03

1997-02-18

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

424 121, 424 7804, 424 7806, 424428, 424450, 427 214, 4284022, 436829, 514 62, A61K 9127, B01J 1320

Patent

active

056038720

ABSTRACT:
Recognizing substances, including epidermal growth factor, gelatin, collagen and hyaluronic acid, have been covalently bound to liposomal surfaces and utilized to attach liposomes onto a cellular or an extracellular matrix (ECM) target site. These "bioadhesive" liposomes offer several advantages including the mutual protection of both the drug and biological environment; an increase in drug bioavailability and retention at the target site; and improved adherence or adhesion to the designated target site.

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