Method of binding collagen recognizing substances to liposomes

Details Method of binding collagen recognizing substances to liposomes Method of binding collagen recognizing substances to liposomes

1996-12-10

1998-12-08

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 43, 424 121, 424 7804, 424 7806, 424428, 427 214, 4284022, 436829, 514801, A61K 9127, B01J 1302

Patent

active

058465618

ABSTRACT:
Recognizing substances, including epidermal growth factor, gelatin, collagen and hyaluronic acid, have been covalently bound to liposomal surfaces and utilized to attach liposomes onto a cellular or an extracellular matrix (ECM) target site. These "bioadhesive" liposomes offer several advantages including the mutual protection of both the drug and biological environment; an increase in drug bioavailability and retention at the target site; and improved adherence or adhesion to the designated target site.

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