Method of binding a biologically active material to a carrier co

Details Method of binding a biologically active material to a carrier co Method of binding a biologically active material to a carrier co

1981-11-12

1983-10-25

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an organic...

435180, 435181, C12N 1112, C12N 1108, C12N 1106

Patent

active

044120001

ABSTRACT:
Biologically active material such as an enzyme is bonded to a carrier containing hydroxyl groups by binding an isocyanate compound to the carrier and bonding the biologically active material to the bound isocyanate compound. Binding of the isocyanate compound to the carrier is achieved with the use of a non-toxic titanium based compound which catalyzes the formation of urethane bonds. The preferred non-toxic based titanium compound is an orthotitanium acid ester such as tetrabutyltitanate.

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Chen, et al., Physical Characteristics of Porous Cellulose Beads as Supporting Material for Immobilized Enzymes. Biotech. and Bioeng. vol. XVIII, 1976 (pp. 1507-1516).
Reichelt et al., Uber die Umsetzung von Cellulose und Lignin mit Isocyanaten bzw. isocyanatgruppenhaltigen Prapolymeren, Acta Polymerica, vol. 32, 1981 (pp. 172-176).
Zaborsky, O., Immobilized Enzymes CRC Press Cleveland, Ohio 1973 (pp. 21-22).
Axen, et al., Chemical Fixation of Enzymes to Cyanogen Halide Activated Polysaccharide Carriers, Eur. J. Biochem. vol. 18, 1971 (pp. 351-360).
Jackson, et al., A New Extracorporeal Reactor-Dialyzer for Enzyme therapy Using Immobilized Asparaginase, The Journal of Pharm. and Exp. Therapeutics vol. 209, No. 2, 1979 (pp. 271-274).
Pommerening et al., Problems of Matrix Activation in Using The cyanogen Bromide Method, Journal of Polymer Science; Polymer Symposium, vol. 66, 1979 (pp. 185-188).
Lesiak et al., Chemistry and Application of Organic Isocyanates IV. Die Angewandte Makromolekulare Chemie, vol. 88, 1980 (pp. 179-191).

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