Method of attenuating physical damage to the spinal cord

Details Method of attenuating physical damage to the spinal cord Method of attenuating physical damage to the spinal cord

1994-04-14

1996-11-12

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514165, 514169, 514171, 514177, 514178, 514182, 514885, 5361231, A61K 31715, A61K 3160, A61K 3156

Patent

active

055740227

ABSTRACT:
A method is disclosed for attenuation of nervous system damage after injury which comprises administering therapeutic amounts of PREG, PREG-S, or esters of PREG or PREG-S together with an enhancer of secretory processes in non-neural cells such as a bacterial lipopolysaccharide and a non-steroidal antiinflammatory substance such as indomethacin.

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patent: 5212167 (1993-05-01), Farb
patent: 5366968 (1994-11-01), Farb
Faden, et al, "Comparison of Thyrotropin-releasing Hormone (TRH), Naloxone, and Dexamethasone Treatments in Experimental Spinal Injury", 1983, Neurology, V33 N6, pp. 673-678. (Jun. 1983).
Ducker, "Treatment of Spinal-Cord Injury", The New England Journal of Medicine V322 N20, pp. 1459-1460. (May 17, 1990).
Bracken, et al., "A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury", The New England Journal of Medicine V322 N20, pp. 1405-1411. (May 17, 1990).
Guth, et al., "Spinal Cord Injury in the Rat: Treatment with Bacterial Lipopolysaccharide and Indomethacin Enhances Cellular Repair and Locomotor Function", Experimental Neurology 126, 1-1, pp. 1-12. (1994).
Wu et al. Molecular Pharmacology, vol. 40, pp. 333-336, (1991).
Carbohydrate Chemistry, Ed. by John F. Kennedy, Clarendon Press, pp. 251-255, (1988).

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