Method of attenuating arterial stenosis

Details Method of attenuating arterial stenosis Method of attenuating arterial stenosis

1996-07-03

1998-10-20

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 21, 530324, 530350, 530380, 424422, A61K 3800, C07K 1400, A61F 1300

Patent

active

058246444

ABSTRACT:
A method is disclosed for attenuating stenosis after balloon angioplasty. The method comprises administering to a host parenterally or locally to the luminal surface of the blood vessel subjected to said balloon angioplasty an effective amount of tissue factor pathway inhibitor (TFPI) for a prolonged period of time sufficient to substantially reduce the extent of restenosis. An exemplary amount of the TFPI is from about 0.5 mg/kg to about 6 mg/kg during a prolonged administration of about twelve (12) hours to 36 hours.

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