Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-12-27
1998-10-20
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514723, 514743, 514746, 514753, 514756, 514759, A61K 3134
Patent
active
058247033
ABSTRACT:
A method of assisting a mammal having a lung disorder to breathe ambient gas normally, i.e., without the assistance of a ventilator. The method includes providing an animal having a lung disorder, such as surfactant deficiency, stiff lung, or hyperinflated lung syndrome, and instilling a minimum effective dose of a perfluorochemical liquid or emulsion through the trachea for coating the alveolar sacs of a lung of the mammal. The preferred perfluorochemicals have a very low vapor pressure to avoid inducing hyperinflated lung syndrome and are supplied in a minimum effective dosage sufficient to coat the inner lung surfaces. The perfluorochemicals are permeable to the ambient gas and reside substantially permanently within the alveolar sacs without inducing hyperinflated lung syndrome. The liquid is instilled in an amount sufficient to enable the animal to breathe the ambient gas normally with O.sub.2 /CO.sub.2 blood gas exchange. Effective coating of the lungs with a small (generally <0.1 ml/kg) dose of very low vapor pressure perfluorochemical is achieved through administration of an aqueous emulsion of the perfluorochemical or a mixture of the very low vapor pressure compound in a larger volume of a higher vapor pressure carrier perfluorochemical.
REFERENCES:
patent: 3911138 (1975-10-01), Clark, Jr.
patent: 4173654 (1979-11-01), Scherer
patent: 5158536 (1992-10-01), Sekins et al.
patent: 5295953 (1994-03-01), Richard et al.
patent: 5300528 (1994-04-01), Graybill et al.
patent: 5437272 (1995-08-01), Fuhrman
Van Nostraud's Chemist's Dictionary, p. 518 1962.
Hoffman, R.E. et al., Biomat., Art, Cells & Immob. Biotech.,"Arterial Blood Gases and Brain Oxygen Availability Following Infusion of Intratracheal Fluorocarbon Neat Liquids," 20 (2-4), 1073-1073, .COPYRGT.1992 by Marcel Dekker, Inc.
Leach, C.L. et al., Critical Care Medicine, "Perfluorocarbon-associated gas exchange (partial liquid ventilation) in respiratory distress syndrome: A prospective, randomized, controlled study," vol. 21, No. 9, .COPYRGT.1993 by Williams & Wilkins.
Clark, L.C., Jr. et al., Biomat., Art, Cells & Immob. Biotech., "Response of the Rabbit Lung as a Criterion of Safety for Fluorocarbon Breathing and Blood Substitutes," 20 (2-4), 1085-1099, .COPYRGT.1992 by Marcel Dekker, Inc.
Tutuncu, A.S. et al., American Review of Respiratory Disease, "Comparison Ventilatory Support with Intratracheal Perfluorocarbon Administration and Conventional . . . Acute Respiratory Failure," vol. 148, pp. 785-792 (1993).
Cook Rebecca
Synthetic Blood International, Inc.
LandOfFree
Method of assisting normal breathing in a mammal having a lung d does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of assisting normal breathing in a mammal having a lung d, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of assisting normal breathing in a mammal having a lung d will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-244798