Method of assessing reperfusion after thrombolytic therapy

Details Method of assessing reperfusion after thrombolytic therapy Method of assessing reperfusion after thrombolytic therapy

1992-03-31

1993-09-21

Cohen, Lee S.

Surgery

Truss

Pad

A61B 500

Patent

active

052460010

ABSTRACT:
The present invention is a method of diagnosing the presence of a persistent occlusion in a myocardial infarct patient undergoing thrombolytic therapy. The method comprises detecting a series of three variables from the patient and then generating the probability of the presence of a persistent occlusion from those variables. The first variable comprises a serum creatine kinase MB (CK-MB) level from a patient at the onset of thrombolytic therapy. The second variable comprises a second CK-MB level in the patient at a predetermined time after the onset of thrombolytic therapy. The third variable comprises the presence or absence of chest pain a predetermined time after the onset of thrombolytic therapy. In a preferred embodiment of the present invention, the second and third variables are detected within 30 minutes of each other and within about 1 to about 3 hours after the initial variable is detected. In an alternate embodiment a fourth variable reflecting the time from onset of chest pain to the beginning of thrombolytic therapy is included in the regression model.

REFERENCES:
Schoiler, V; Thode, J; Kjoller, E; "Performance characteristics of creatine kinase-MB isoenzyme measured with an immunoenzymometric and an immunoinhibition assay in acute myocardial infarction with and without thrombolytic therapy"; Jun. 1992; European Journal of Clinical Chemistry and Clinical Biochemistry; p. 357-361 Abstract.
Hohnloser, Stefan H., et al. "Assessment of Coronary Artery Patency After Thrombolytic Therapy: Accurate Prediction Utilizing the Combined Analysis of Three Noninvasive Markers", JACC vol. 18, pp. 44-99 (1991).
Christenson, Robert H., "Myocardial Injury: Diagnosis, Monitoring and Prognosis in the Thrombolytic Era" Clinical Chemistry, vol. 37, No. 6 (1991).
Christenson, Robert H., "Non-Invasive Monitoring of Thrombolysis After Mycardial Infarction", Clinical Chemistry, vol. 37, No. 6 (1991).
Christenson, Robert H., et al. "Release of the Tissue Specific MM-3 and MB-2 Isoforms of Creatine Kinase is Simultaneous During Reperfusion after Myocardial Infarction", Circulation 1990; 82 (Suppl. III) III-297.
Ohman, E. Magnus, et al., "Non-Invasive Detection of Reperfusion after Thrombolysis Using Rapid CK-MB Analysis", Circulation 1990; 82 (Suppl. III) III-281.
Creatine Kinase Isoenzymes, Edited by H. Lang, Springer-Verlag, 1981, Chapter 1.

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