Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-12-12
2006-12-12
Andres, Janet L. (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007210, C435S007230
Reexamination Certificate
active
07148027
ABSTRACT:
A method of measuring the individual response to antidepressant drug therapy on the transport inhibition of monoamine neurotransmitters involves in vitro monitoring of radiolabeled monoamine neurotransmitter transport into cells transfected with transport proteins similar to those on neural cells of the individual being studied. The transport occurs in unbuffered serum of the individual who is undergoing or will later undergo pharmaceutical treatment for depression or other neuropsychiatric disorders. The use of buffers is avoided so that the sensitive balance of bound/free drug within the individuals serum is not disrupted prior to or during testing.
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Michelle L. Gilmor, Ph.D., Michael J. Owens, Ph.D., and Charles B. Nemeroff, M.D., Ph.D.; Inhibition of Norepinephrine Uptake in Patients With Major Depression Treated With Paroxetine; American Journal of Psychiatry; Oct. 2002; pp. 1702-1710.
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Nemeroff Charles B.
Owens Michael J.
Alston & Bird LLP
Andres Janet L.
Emory University
Standley Steven H.
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