Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2005-01-18
2005-01-18
Priebe, Scott D. (Department: 1635)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C424S009200
Reexamination Certificate
active
06844483
ABSTRACT:
The invention features methods for assaying compounds that affect hypertension by using an animal model with a functionally variant hypertension susceptibility gene.
REFERENCES:
patent: 5691310 (1997-11-01), Vesely
VLM Herrera et al., Science, “Alteration of a1 Na+, K+-aTPase 86Rb+ Influx by a Single Amino Acid Substitution,” 1990, vol. 249, pp. 1023-1026.*
RJ Wall, Theriogenology, “Transgenic Livestock: Progress and Prospects for the Future,” 1996, 45:57-68.*
LJ Mullins et al., J Clin. Invest., “Perspectives Series:Molecular Medicine in Genetically Engineered Animals.” Apr. 1996, vol. 97, No. 7, pp. 1557-1560.*
IA Polejaeva et al., Theriogenology, “New Advances in Somatic Cell Nuclear Transfer: Application in Transgenesis,” 2000. 53:117-126.*
JO Bishop, Repro Nutr Dev. “Chromosomal insertion of foreign DNA,” 1996, 36, pp. 607-618.*
L-M Houdebine, Journal of Biotechnology, “Production of pharmaceutical proteins from transgenic animals,”1994, 34: pp. 269-287.*
T Rulicke et al., Experimental Physiology,“Germ line transformation of mammals by pronuclear microinjection,” 2000,085.6,pp. 589-601*
RM Strojek et al., Genetic Engineering: Principles and methods, Plenum Press, 1988, vol. 10, pp. 221-246.*
L Somova et al., Methods Find Exp Clin Pharmacol., “Glucose Metabolism and Insulin Sensitivity in Dahl Hypertensive Rats,” 1999, 21(6) pp. 421-425.*
OS Medvedev et al., Journal of Autonomic Nervous System, “Chronopharmacological dependence of antihypertensive effects of the imidazoline-like drugs in stroke-prone spontaneously hypertensive rats,” 1998, 72, pp. 170-176.*
P Hamet et al., Journal of Hypertension, “Hypertension: Genes and environment,” 1998, vol. 16, pp. 397-418.*
VLM Herrera et al., J Clin Invest., “The a 1 Na, K-ATPase Gene is a Susceptibility Hypertension Gene in the Dahl Salt-Sensitive HSD Rat,” Sep. 1998, vol. 102, No. 6, pp. 1102-1111.*
N Ruiz-Opazo et al., Hypertension, “Pressure-Overload Deinduction of Human a2,Na,K-ATPase Gene Expression in Transgenic Rats,” 1997, 29: 606-612.
Culter Linder, Lab Animal, vol. 30, pp. 34-39, 2001.*
Sigmund, Arterioscler Thromb Vasc Bio. vol. 20:1425-1429, 2000.*
Canessa et al., “The α1 Na(+)-K+ Pump of the Dahl Salt-Sensitive Rat Exhibits Altered Na+Modulation of K+Transport in Red Blood Cells,”J. Membr. Biol134: 107-122, 1993.
Clark et al., “Quantitative Trait Loci in Genetically Hypertensive Rats. Possible Sex Specificity,”Hypertension28: 898-906, 1996.
Dallner, “Isolation of Rough and Smooth Microsome—General,”In Methods in Enzymology, vol. XXXI, S. Fleischer and L. Packer, editors, Academic Press, New York, 31:191-201, 1974.
Deng et al., “Mapping of a Quantitative Trait Locus for Blood Pressure on Rat Chromosome 2,”J. Clin. Invest.94:431-436, 1994.
de Wardener, H.E., The Primary Role of the Kidney and Salt Intake in the Aetiology of Essential Hypertension, Part II,Clin. Sci.79: 289-297, 1990.
Dubay, C. et al., “Genetic Determinants of Diastolic and Pulse Pressure Map to Different Loci in Lyon Hypertensive Rats,”Nat. Genet.3: 354-357, 1993.
Goldman, “High Anxiety,”Science274: 1483, 1996.
Herrera and Ruiz-Opazo “Beyond Genetic Markers: Hypertension Genes,”J. Hypertension12: 847-856, 1994.
Herrera et al., “Developmental Cell-Specific Regulation of Na(+)-K(+)-ATPase α1-, α2-, and α3-isoform gene expression,”Am. J. Physiol.266: C1301-C1312, 1994.
Jacob et al., “A Genetic Linkage Map of the Laboratory Rat,Rattus Norvegicus,”Nat. Genet9: 63-69, 1995.
Lander and Kruglyak, “Genetic Dissection of Complex Traits: Guidlines for Interpreting and Reporting Linkage Results,”Nat. Genet.11:241-247, 1995.
Lesch et al., “Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region,”Science274: 1527-1531, 1996.
Lewis et al., “Analysis of the Genetic Contamination of Salt-Sensitive Dahl/Rapp Rats,”Hypertension24: 255-259, 1994.
Orosz and Hopfer, “Pathophysiologic Consequences of Changes in the Coupling Ratio of Na,K-ATPase for Renal Sodium Reabsorption and its Implications for Hypertension,”Hypertension27:219-227, 1996.
Raij et al., “Mesangial Immune Injury, Hypertension, and Progressive Glomerular Damage in Dahl Rats,”Kidney Int.26: 137-143, 1984.
Rapp and Dene, “Development and Characteristics of Inbred Stains of Dahl Salt-Sensitive and Salt-Resistant Rats,”Hypertension7: 340-349, 1985.
Ruiz-Opazo et al., “Confirmation of Mutant α1 Na,K-ATPase Gene and Transcript in Dahl Salt-Sensitive/JR Rats,”Hypertension24:260-270, 1994.
Ruiz-Opazo et al, “Characterization of a Sodium-Response Transcriptional Mechanism,”Hypertension30: 191-198, 1997.
Samani et al., “Analysis of Quantitative Trait Loci for Blood Pressure on Rat Chromosomes 2 and 13. Age-Related Differences in Effect,”Hypertension28: 1118-1122, 1996.
Shull et al., “Molecular Cloning of Three Distinct Forms of the Na+,K+-ATPase αSubunit From Rat Brain,”Biochemistry25 8125-8132, 1986.
Simonet et al., “Sequence Analysis of the α1 Na+, K+-ATPase Gene in the Dahl Salt-Sensitive Rat,”Hypertension18:689-693, 1991.
St. Lezin et al., “Genetic Contamination of Dahl SS/JR Rats: Impacts on Studies of Salt-Sensitive Hypertension,”Hypertension23: 786-790, 1994.
Herrera Victoria L. M.
Ruiz-Opazo Nelson
Clark Paul T.
Clark & Elbing LLP
NoMI LLC
Priebe Scott D.
Whiteman Brian
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