Method of assaying kallikrein formation substances

Details Method of assaying kallikrein formation substances Method of assaying kallikrein formation substances

1987-09-10

1991-01-15

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

435 23, 435 24, 435184, 436 69, C12Q 137, C12Q 156, G12N 999

Patent

active

049853546

ABSTRACT:
A method of assaying a physiologically active substance, which comprises activating blood coagulation factor XII in plasma in the presence of said physiologically active substance being tested to convert prekallikrein in the plasma into kallikrein, and measuring the activity of kallikrein thus formed.

REFERENCES:
Bergmeyer, H. U., vol. II, "Samples, Reagents, Assessment of Results", in Methods of Enzymatic Analysis, (Verlag Chemie, Weinheim, Germany), pp. 442 and 445.
Bergmeyer, H. U., vol. V, "Enzymes 3: Peptidases, Proteinases, and Their Inhibitors", in Methods of Enzymatic Analysis, (Verlag Chemie, Weinheim, Germany), pp. 338 and 411-418, (1984).
Hojima, Y. et al., Biochemistry, 21:3741-3746, (1982).

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