Method of assaying fibrinogen, dry reagent therefor, and process

Details Method of assaying fibrinogen, dry reagent therefor, and process Method of assaying fibrinogen, dry reagent therefor, and process

1993-07-29

1995-08-22

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

435214, 436 46, 436 69, 530381, 530382, 530383, 530384, 422 73, C12Q 156, G01N 3386, C07K 1475

Patent

active

054439590

ABSTRACT:
A dry reagent consisting essentially of (a) a protein having thrombin activity, (b) at least one additive selected from the group consisting of amino acid, a salt thereof and saccharide and optionally (c) magnetic particles, and a method of assaying fibrinogen in an assay sample using the above dry reagent. The dry reagent obviates the time required for preparing a reagent and warming an assay sample, and permits facile fibrinogen assay by only diluting an assay sample. The fibrinogen assay range being broad, the dry reagent substantially obviates the procedure of remeasuring plasma having a fibrinogen concentration outside the assay range of a liquid reagent. The assay result by the dry reagent and that by a liquid reagent well correlate with each other as compared with the result by any known thrombin-containing dry reagent, and the assay by the dry reagent can be performed with good reproducibility in achievement and reliability in measurement.

REFERENCES:
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patent: 5059525 (1991-10-01), Bartl et al.
patent: 5110727 (1992-05-01), Oberhardt
Oberhardt et al, Clin. Chem, vol. 37, No. 4, pp. 520-526, 1991.
Gorczynsha et al, Chemical Abstracts, vol. 101, p. 419, Ref. No. 213072, 1984.
Sane et al, Biological Abstracts, vol. 94, No. 1, Ref. No. 8551, 1992.

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