Method of assaying collagen fragments in body fluids, a test kit

Details Method of assaying collagen fragments in body fluids, a test kit Method of assaying collagen fragments in body fluids, a test kit

1997-11-04

2000-08-29

Stucker, Jeffrey

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 793, 435 794, 435 7021, 435331, 435975, 436518, 436536, 436548, 436815, 530300, 530323, 530328, 5303879, 5303881, 5303911, 5303913, G01N 3353

Patent

active

061106895

ABSTRACT:
A method of assaying collagen fragments in body fluids, including bringing a sample of body fluid in contact with at least one immunological binding partner for the collagen fragments, said binding partner being immunoreactive with synthetic peptides, the sequences of which are essentially derived from collagen and containing potential sites for cross-linking. The immunological binding partners are incorporated, either as whole antibodies or as immunologically active fragments thereof, in an assay for quantitative determination of collagen fragments in the sample. In addition to being contacted with the immunological binding partner(s), the sample may be brought into direct contact with the corresponding synthetic peptide. The invention further comprises a test kit and specific means for carrying out the method. The structure of specific peptides is also described.

REFERENCES:
patent: 3600132 (1971-08-01), Goverde
patent: 4312853 (1982-01-01), Timpl
patent: 4504587 (1985-03-01), Timpl et al.
patent: 4628027 (1986-12-01), Gay
patent: 4778768 (1988-10-01), Heinegard et al.
patent: 5300434 (1994-04-01), Eyre
patent: 5320970 (1994-06-01), Eyre
patent: 5455179 (1995-10-01), Eyre
patent: 5472884 (1995-12-01), Eyre
patent: 5473052 (1995-12-01), Eyre
patent: 5532169 (1996-07-01), Eyre
patent: 5576189 (1996-11-01), Eyre
patent: 5607862 (1997-03-01), Eyre
patent: 5641687 (1997-06-01), Eyre
patent: 5641837 (1997-06-01), Eyre
patent: 5652112 (1997-07-01), Eyre
patent: 5656439 (1997-08-01), Eyre
patent: 5753450 (1998-05-01), Baylink
Harlow et al., "Antibodies--A Laboratory Manual", Cold Spring Harbor, (1988), pp. 72-77.
Delmas et al., "Biochemical Markers of Bone Turnover for the Clinical Assessment of Metabolic Bone Disease", Endocrinology and Metabolism Clinics of North America, vol. 19, No. 1, (1990), pp. 1-18.
Mintz et al., "Detection of Procollagen Biosynthesis Using Peptide-Specific Antibodies," Matrix, vol. 10, No. 3, pp. 186-199 (1990).
Schroter-Kermani, C. et al., Immunol Invest 19(5-6);475-91, Oct.-Dec. 1990.
Otter, A. et al., J. Biomol. Struct. Dyn., 7(3):455-76, Dec. 1989.
Werkmeister, J.A. et al. Eur J Biochem 187(2):439-43, Jan. 26, 1990.
Delmas PD et al., J Bone Min. Res, 1:333-337 (1986).
Loidl et al., Nucleic Acids Research, 12:9383-9394 (1984).
Sangiorgi et al., Nucleic Acids Research, 13:2207-2225 (1985).
Baldwin et al., Biochem J, 262:521-528 (1989).
Ala-Kokko et al., Biochem J, 260:509-516 (1989).
Kuhn K, in Immunochemistry of the Extracellular Matrix, 1:1-29, CRC Press, Inc., Boca Raton, Florida (1982).
Eyre DR, Ann.Rev.Biochem, 53:717-748 (1984).
Singer FR et al., Metabolic Bone Disease, vol. II (eds. Avioli LV and Kane SM), 489-575 (1978), Academic Press, New York.
Russell et al., Metab. Bone Dis. and Rel. Res. 4 and 5, 225-262 (1981).
Kiviriko KI, Int.Rev.Connect.Tissue Res, 5:93 (1979).
Weiss PH and Klein L, J Clin Invest, 48:1 (1969).
Wu and Eyre, Biochemistry, 23:1850 (1984).
Black et al., Annals of the Rheumatic Diseases, 48:641-644 (1989).
Robins et al., Annals of the Rheumatic Diseases, 45:969-973 (1986).
Seibel et al., The Journal of Dermatology, 16:964 (1989).
Hanson et al., Journal of Bone and Mineral Research, 7:1251-1258 (1992).
Pierard et al., Analytical Biochemistry, 141:127-136 (1984).
Niemela, Clin.Chem., 31/8:1301-1304 (1985).
Rohde et al., European Journal of Clinical Investigation, 9:451-459 (1979).
Dodge, J. Clin.Invest, 83:647-661 (1981).
Campell AM, Laboratory Techniques in Biochemistry and Molecular Biology, vol. 13 (1986), pp. 66-165.
Morein B et al., Nature, 308:457-460 (1984).
Goding JW, in Monoclonal Antibodies: Principles and Practice (1986), pp. 59-103.
Ishikawa E, Journal of Immunoassay, 3:209-327 (1983).
Uebelhart D, Bone and Mineral, 8:87-96 (1990).
Chu ML, de Wet W, Bernard M, Ding JF, Morabito M, Myers J, Williams C, and Ramirez F, Nature, 310:337-340 (1984).
Click EM and Bornstein P, Biochemistry, 9:4699-4706 (1970).
Morgan PH, Jacobs HG, Segrest JP, and Cunningham LW, J.Biol.Chem., 245:5042-5048 (1970).
Bernard MP, Chu ML, Myers JC, Ramirez F, Eikenberry EF, and Prockop DJ, Biochemistry, 22:5213-5223 (1983).
de Wet W, Bernard M, Benson-Chanda V, Chu ML, Dickson L, Weil D, and Ramirez F, J.Biol.Chem, 262:16032-16036 (1987).
Su MW, Lee B, Ramirez F, Machado M, Horton W, Nucleic Acids Res, 17:9473 (1989).
Ala-Kokko L, Baldwin CT, Moskowitz RW, and Prockop DJ, Proc.Natl.Acad.Sci, 87:6565-6568 (1990).
Vikkula M and Peltonen L, FEBS Lett, 250:171-174 (1989).
Janeczko RA and Ramirez F, Nucleic Acids Res, 17:6742 (1989).
Beardsworth et al., 1990, "Changes with age in the urinary excretion of lysyl- and hydroxylysylpyridinoline, two new markers of bone collagen turnover", J. Bone Miner. Res. 5:671-676.
Black et al., 1988, "Quantitative analysis of the pyridinium crosslinks of collagen in urine using ion-paired reversed-phase high-performance liquid chromatography", Ana. Biochem. 169:197-203.
del Pozo et al., 1986, "Binding of 1-anilinophthalene-8-sulfonic acid to type I collagen" Int. J. Pept. Protein Res. 28:173-178.
P.D. Delmas, 1990, "Biochemical markers of bone turnover for the clinical assessment of metabolic bone disease", Metabolic Bone Dis. 19:1-18.
Dickson et al., 1993, "Pyridonolines and cross-linked type I collagen N-telopeptides as markers of bone metastases in breast cancer" 15.sup.th Annual Mtg of the Amer Soc for Bone .
Eyre et al., 1988, "Identification of urinary peptides derived from cross-linking sites in bone collagen in Paget's disease", J. of Bone & Mineral Res 3:S210, Abst.565.
D.R. Eyre, 1994, "New molecular markers of bone metabolism", Ther. Res. (Symposium) 15:532-535.
D. Fujimoto, 1980, "Evidence for natural existence of pyridinoline crosslink in collagen", Biochem & Biophys. Res. Comm. 93:948-953.
Fujimoto et al., 1983, "Analysis of pyridinoline, a cross-linking compound of collagen fibers, in human urine", J. Biochem. 94:1133-1136.
H. Furthmayr, 1982, "Immunization procedures, isolation by affinity chromatography, and serological and immunochemical characterization of collagen specific antibodies", Immunochemistry of the extracellular matrix, H. Furthmayr (ed.), CRC Press, vol. 1, Chap. 11, pp. 143-178.
Gertz et al., 1994, "Monitoring bone resorption in early postmenopausal women by an immunoassay for cross-linked collagen peptides in urine", J. of Bone & Min. Res. 9:135-142.
Gunja-Smith & Boucek, 1981 "Collagen cross-linking compounds in human urine", Biochem. J. 197:759-762.
Hanson et al., 1992, "A specific immunoassay for monitoring human bone resorption: Quantitation of type I collagen cross-linked N-telopeptides in urine", J. of Bone & Min. Res. 7:1251-1258.
Hassager et al., 1994, "The carboxy-terminal pyridinoline cross-linked telopeptide of type I collagen in serum as a marker of bone resorption: The effect of nandrolone decanoate and hormone replacement therapy", Calcif. Tissue Int. 54:30-33.
Henkel et al., 1987, "Characterization of type-I collagen trimeric cross-linked peptide from calf aorta and its cross-linked structure", Eur. J. Biochem. 165:427-436.
Kruger-Franke, 1991, "Pyridinoline-containing collagen degradation products in the urine of patients with osteoarthrosis of the hip joint", Z. Rheumatol. 50:323-327 (German with English Translation).
Kuboki et al., 1981, "Location of the intermolecular cross-links in bovine dentin collagen, solubilization with trypsin and isolation of cross-link peptides containing dihydroxylysinonorleucine and pyridinoline", Biochem. & Biophys. Res. Comm. 102:119-126.
K. Kuhn, 1982, "Chemical properties of collagen", Immunochemistry of the Extracellular Matrix, H. Furthmayr (ed.), CRC Press, vol. 1, Chap. 1, pp. 1-23.
K. Kuhn, 1987, "The classical collagens: Types I, II, and III", Structure & Function of Collagen Types, Mayne & Bergeson (eds.), Academic Press, Chap 1, pp. 10-23.
Kuypers et al., 1992, "Identification of the loci of the collagen-associated Ehrlich chromogen in type I collagen confirms its role as a trivalent cross-link", Biochem. J. 282:129-136.
Macek & Adam, 1987, "Determination of collagen degradation products in human urine in osteoarthrosis", Z. R

Affiliated with

Also associated with

Rating

Method of assaying collagen fragments in body fluids, a test kit does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of assaying collagen fragments in body fluids, a test kit, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of assaying collagen fragments in body fluids, a test kit will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1248460