Method of assaying cellular adhesion with a coated biochip

Details Method of assaying cellular adhesion with a coated biochip Method of assaying cellular adhesion with a coated biochip

2006-10-17

2006-10-17

Gitomer, Ralph (Department: 1655)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C422S051000

Reexamination Certificate

active

07122301

ABSTRACT:
Biological assays using various constructions of biochips are disclosed to mirror in vivo situations. The biochip50comprises a microchannel51having a liquid outlet port1, bubble release port2and a liquid outlet port3with an associated bubble release port4. A multiplicity of tests can be performed often by coating the bore of the microchannel50which various adhesion mediating proteins or the use of chemoattractants. The assay assembly60comprises a syringe pump feeding the biochip50. An inverted microscope65, digital camera66and recorder67are provided. A sample liquid containing cells in suspension is injected slowly through the biochip and the effect of the assay recorded over a long period.

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