Method of assaying antilaminin-1 antibody and application...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007100, C435S007200, C435S007210, C435S007920, C435S007930, C436S506000, C436S518000, C436S528000, C436S534000, C436S536000, C436S538000, C436S811000, C436S906000, C600S033000

Reexamination Certificate

active

07029867

ABSTRACT:
By allowing serum or plasma samples collected from humans to react with laminin-1 or a fragment thereof, and then determining whether or not anti-laminin-1 antibody, an auto-antibody against laminin-1, in the sample bound to laminin-1 to detect anti-laminin-1 antibody in the sample, gynecology-related diseases such as habitual abortion, sterility, infertility, and endometriosis can be diagnosed.

REFERENCES:
patent: 4340581 (1982-07-01), Timpl
patent: 5789260 (1998-08-01), Naparstek
patent: 4-134097 (1992-05-01), None
Inagaki et al., Apr. 2001. IgG anti-laminin-1 autoantibody and recurrent miscarriages. American Journal of Reproductive Immunology 45: 232-238.
Foidart et al., 1986. Antibodies to laminin in preeclampsia. Kidney International 29: 1050-1057.
Bernard et al., 1986. Detection of anti-laminin antibodies in sera by latex agglutination. Clinical Chemistry 32: 1468-1472.
Chambers et al., 1995. Reproduction and sera embryotoxicity after immunization of monkeys with the laminin peptides YIGSR, RGD, and IKVAV. Proceedings of the National Academy of Sciences USA 92: 6818-6822.
Qureshi et al., Sep. 2000. Anti-DNA antibodies cross-reacting with laminin i9nhibit trophoblast attachment and migration: implications for recurrent pregnancy loss in SLE patients. American Journal of Reproductive Immunology 44: 136-142.
Church et al., 1997. Anti-laminin autoantibodies in recurrent miscarriager patients. Placenta 18: A17.
Yurchenco et al., 1993. Recombinant laminin G domain mediates myoblast adhesion and heparin binding. Journal of Biological Chemistry 268 (11): 8356-8365.

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