Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Patent
1998-08-10
1999-08-10
Gitomer, Ralph
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
435214, C12Q 156
Patent
active
059358025
ABSTRACT:
An improved method of assaying undiluted whole blood or undiluted plasma for prothrombin is disclosed. The improved method utilizes carinactivase-1 and calcium ions, and eliminates the need for a prothrombin-deficient plasma as a reference plasma.
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Yamada et al., "Isolation and characterization of carinactivase, a novel prothrombin activator in Echis carinatus venom with a unique catalytic mechanism," The Journal of Biological Chemistry, vol. 271, No. 9, pp. 5200-5207, (1996).
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Rob J., A Rapid and Highly Sensitive Chromogenic Microplate Assay for Quaitification of Rat and Human Prothrombin, Anal Biochem 245 222-225, Feb. 1997.
Evanston Northwestern Healthcare Research Institute
Gitomer Ralph
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