Method of and dosage unit for inhibiting angiogenesis or vascula

Details Method of and dosage unit for inhibiting angiogenesis or vascula Method of and dosage unit for inhibiting angiogenesis or vascula

1990-02-12

1991-12-24

Page, Thruman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424436, 424451, 424464, 424DIG15, 424548, 514966, A61K 902, A61K 920, A61K 948

Patent

active

050751123

ABSTRACT:
Method of, and dosage unit for, inhibiting angiogenesis in an aminal having an intestinal wall by administering to the animal, orally or anally, an effective amount of shark cartilage, particularly finely divided shark cartilage in solid dosage form such as a tablet, capsule, suppository, for passing through the intestinal wall of the animal as a suspension.

REFERENCES:
patent: 3966908 (1976-06-01), Balassa
patent: 4444752 (1984-04-01), Prudden
patent: 4656137 (1987-04-01), Balassa
Oikawa, T., A Novel Angiogenic Inhibitor Derived from Japanese Shark Cartilage (I), Cancer Letters, vol. 51, pp. 181-186, 1990.
Lee, A., Shark Cartilage Contains Inhibitors of Tumor Angiogenesis, Science, vol. 221, pp. 1185-1187, 1983.
Leur, C. A., Inhibitors of Angiogenesis from Shark Cartilage, Tumor Biology, abstract 4624, p. 949.
D'Amore, P., Antiangiogenesis as a Strategy for Antimetastasis, Seminars in Thrombosis & Hemostasis, vol. 14, No. 1, 1988.
Folkman, J., Vascularization of Tumors, Sci. Am. 234:58-73, 1976.
Folkman, J. and Klagsburn, M., Angiogenic Factors, Science, vol. 235, pp. 442-447, Jan. 1987.

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