Method of and compounds for treatment for cystic fibrosis

Details Method of and compounds for treatment for cystic fibrosis Method of and compounds for treatment for cystic fibrosis

1993-03-02

1995-01-24

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424 45, 424436, 424449, 424451, 424464, 436829, 514937, 514962, 514963, A61K 3722, A61K 970, A61F 902, A61L 904

Patent

active

053841280

ABSTRACT:
This invention provides a method and compositions for increasing the permeability of epithelial cells to a chloride ion in a subject comprising administering a permeability enhancing amount of a composition comprising a nontoxic, nonionic surfactant having (1) a critical micelle concentration of less than about 10 mM and a hydrophile-lipophile balance number of from about 10 to 20 and (2) a suitable hydrophobic organic group joined by a linkage to a suitable hydrophilic polyol.

REFERENCES:
patent: 4826679 (1989-05-01), Roy
Physicians' Desk Reference, 47th Ed., Medical Economics Data, Montvale, N.J., pp.782-785 (1993).
Eduardo F. Tizzano et al., "Cystic Fibrosis: Beyond the Gene to Therapy," The Journal of Pediatrics, 120(3):337-349 (Mar. 1992).
Richard C. Boucher, "Drug Therapy in the 1990s: What Can We Expect for Cystic Fibrosis?" Drugs, 43(4):431-439 (1992).
Michael R. Knowles et al.,"A Pilot Study of Aerosolized Amiloride for the Treatment of Lung Disease in Cystic Fibrosis," N. Eng. J. Med., 322:1189-1194 (1990).
Igor M. Gladstone et al., "Effect of Artificial Surfactant on Pulmonary Function in Preterm and Full-Term Lambs," J. Appl. Physiol., 69:465-472 (1990).
Nikolaus Weber et al., "Metabolism of Orally Administered Alky .beta.-Glycosides in the Mouse," J. Nutr., 114:247-254 (1984).

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