Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations
Patent
1987-03-18
1990-12-04
Ore, Dale R.
Drug, bio-affecting and body treating compositions
Topical sun or radiation screening, or tanning preparations
424 60, 514844, 514847, 514886, 514887, 514937, 514938, A61K 740, A61K 742, A61K 744, A61K 748
Patent
active
049752723
ABSTRACT:
A method of and composition for the prevention of solar radiation absorption-induced formation of carcinogenic skin lipid degradation products, particularly malonaldehyde, consisting of the application, prior to exposure of the skin to natural or artificial sources of solar radiation, of a composition comprising an ultraviolet screen--effective amount of an ultraviolet absorbing compound selected from the group consisting of a salicylate, a para-aminobenzoate, an alkyl ester of para-dialkylaminobenzoic acid, a benzophenone, a cinnamate, a napthoate, an acid-esterified gallate and mixtures thereof; at least one non-hindered, non-acid esterified, oil soluble, phenolic substituent-bearing latent oxidation inhibitor compound, such as the tocopherols, alcoholic esters of gallic acid, nordihydroguaiaretic acid, and mixtures thereof, the total concentration of said inhibitor present constituting a pro-oxidant-effective amount sufficient to demonstrate pro-oxidant properties, said inhibitor concentration further being insufficient to constitute an ultraviolet screen-effective amount demonstrating ultraviolet screening properties; and an inert carrier vehicle for said compounds comprising an oil soluble component, the vehicle being non-toxic and non-irritating to the skin. Utilization of an oil soluble ultraviolet absorbing compound obviates the necessity for a separate oil soluble component-containing carrier vehicle.
REFERENCES:
patent: 4144325 (1979-03-01), Voyt
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