Method of and apparatus for measurement of blood flow using cohe

Surgery – Truss – Perineal

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356 28, G01P 336

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active

041096479

ABSTRACT:
An apparatus for measuring the flow parameter of blood flowing in an organ includes a laser and associated optics which effect the illumination of tissues. The laser light, scattered by the tissues, emerges with a spectrum broadened by Doppler effect due to motion of red blood cells in the micro-circulation vessels. The light from the tissues is fed to a photomultiplier tube or photodiode via a pinhole mask and interference filter. The photomultiplier tube or photodiode, as a result of beating of various components of the light it receives, produces as its output signals a homodyne or heterodyne spectrum or both. These output signals are fed, via a low pass filter, to a differentiator, which differentiates the output signals from the multiplier tube or photodiode, which are passed by the filter, with respect to time. The output of the differentiator is fed to a root-mean-square (RMS) detector. The low pass filter passes, for example, signals having a frequency up to about 20 KHz. The output (R) from the detector, which represents the blood flow (average percolation) in the tissues plus shot noise, a constant (S), is fed to a digital voltmeter. The voltmeter produces a visible read-out indicative of the output from the detector. The output from the detector is also fed to a calculating circuit which also receives a signal corresponding to the mean current (I) produced by the photomultiplier or photodiode, the calculating circuit effecting a solution to the equation ##EQU1## F.sub.norm is a normalized output signal representation of blood flow parameter.

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Foreman, J. W. Jr. et al., "Fluid Flow Measurements with a Laser Doppler Velocimeter", IEEE Jrnl. Quantum Elec. QE-2, #8, Aug. 1966, pp. 260-266.
Chance, Britton et al., "A Time-Sharing Instrument for Direct Readout of Oxidation-Reduction States in Intra-cellular Compartments of Cardiac Tissue", IEEE Transactions on Biomed Engr., vol. BME-17, No. 2, Apr. 1970, pp. 118-120.
Stern, N. D., "In-Vivo Evaluation of Micro-circulation by Coherent Light Scattering", Nature vol. 254, Mar. 6, 1975, pp. 56-58.

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