Chemistry: analytical and immunological testing – Peptide – protein or amino acid
Reexamination Certificate
2005-07-04
2011-10-04
Gakh, Yelena G (Department: 1777)
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
C436S173000
Reexamination Certificate
active
08030083
ABSTRACT:
A method for analyzing a structural affinity relationship between plural kinds of proteins and a compound, comprising the steps of (a) using a compound-immobilized carrier to purify plural kinds of proteins bound to the compound on the carrier, from a group of isotope-labeled proteins; (b) using a compound-immobilized carrier to purify plural kinds of proteins bound to the compound on the carrier, from a group of proteins brought into contact with a compound beforehand; (c) mixing the proteins obtained in step (a) and step (b); (d) analyzing the mixture obtained in step (c) with mass spectrometry; (e) identifying each of plural kinds of proteins based on information obtained by the mass spectrometry; and (f) obtaining an intensity ratio between a labeled peak and a non-labeled peak of each protein, thereby quantitating an affinity ratio of the compound to each protein.
REFERENCES:
patent: 1 686 372 (2006-08-01), None
patent: 2003-177131 (2003-06-01), None
patent: WO 02/48716 (2002-06-01), None
Aebersold et al. (“Mass spectrometry-based proteomics,” Nature 2003, 422, 198-207).
Griffith et al. (“Methionine aminopeptidase (type 2) is a common target for angiogenesis inhibitors AGM-1470 and ovalicin,” Chemistry & Biology 1997, 4, 461-471).
Kudo et al. (“Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region,” Proc. Natl. Acad. Sci. USA 1999, 96, 9112-9117).
Sechi et al. (“Quantitative proteomics using mass spectroscopy,” Current Opinion in Chemical Biology 2003, 7, 70-77, available Feb. 2003).
Oda et al. (“Quantitative Chemical Proteomics for Identifying Candidate Drug Targets,” Anal. Chem. 2003, 75, 2159-2165, available Apr. 3, 2003).
Graves et al. (“Discovery of Novel Targets of Quinoline Drugs in the Human Purine Binding Proteome,” Molecular Pharmacology 2002, 62,1364-1372.).
Aebersold (“Constellations in a cellular universe,” Nature 2003, 422, 115-116).
Szardenings et al. (“Fishing for targets: novel approaches using small molecule baits,” Drug Discovery Today, 2004, 1, 9-15, available Sep. 2004).
Taunton et al. (“A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p,” Science 1996, 272, 408-411).
Sin et al. (“The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAp-2,” Proc. Natl. Acad. Sci., USA 1997, 94, 6099-6103).
Sin et al. (“Eponemycin Analogues: Syntheses and use as Probes of Angiogenesis,” Bioorg. Med. Chem. 1998, 6, 1209-1217).
Philip L. Ross, et al.; “Multiplexed Protein Quantitation inSaccharomyces cerevisiaeUsing Amine-reactive Isobaric Tagging Reagents”; Molecular & Cellular Proteomics 3.12, pp. 1154-1169, ©2004 by the American Society for Biochemistry and Molecular Biology, Inc.
Edited by Hiroshi Terada, Hirokawa, “Kagaku to Seibutsu Jikken Line 48 Tanpakushitsu to Kakusan no Bunri Siesei—Kiso to Jikken -”, 2001, 13.2.4 Defferential display-ho, at p. 457.
Supervised by Shigeo Oono, Yoshifumi Nisimura, “Saibo Kogaku Bessatsu Jikken Protocol Series Tanpakushitsu Jikken Protocol Kino Kaisekihen”, 1997, pp. 157 to 161.
Schulze W., et al.: “A Novel Proteomic Screen for Peptide-Protein Interaction”; The Journal of Biological Chemistry, vol. 279, No. 11, Issue of Mar. 12, 2004, pp. 10756-10764.
Blagoev, B., et al.;“A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling”; Technical Report of Nature Biotechnology, Mar. 2003, vol. 21, pp. 315-318.
Burdine, L., et al.; “Target Identification in Chemical Genetics: The (Often) Missing Link”; Chemistry & Biology, vol. 11, May 2004, pp. 593-597.
Supplementary European Search Report issued for EP 0575 8170, dated Jan. 27, 2010.
Matthew W. Harding, et al.; “A receptor for the immunosuppressant FK506 is acis-transpeptidyl-prolyl isomerase”; Nature, vol. 341, Oct. 26, 1989, pp. 758-760.
Noriaki Shimizu et al.; “High-performance affinity beads for identifying drug receptors”; Nature Biotechnology, vol. 18, Aug. 2000, pp. 877-881.
Eric C Griffith, et al.; “Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin”; Chemistry & Biology, 1997, vol. 4, No. 6, pp. 461-471.
M. Knockaert, et al.; “Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors”; Chemistry & Biology 2000, vol. 7, No. 6, pp. 411-422.
M. Knockaert, et al.; “Intracellular Targets of Paullones”; The Journal of Biological Chemistry, vol. 277, No. 28, Issue of Jul. 12, 2002, pp. 25493-25501.
Joachim B. Schnier, et al.; “Identification of cytosolic aldehyde dehydrogenase 1 from non-small cell lung carcinomas as a flavopiridol-binding protein”; FEBS Letters 454, 1999, pp. 100-104.
Astrid Kaiser, et al.; “The Cyclin-Dependent Kinase (CDK) Inhibitor Flavopiridol Inhibits Glycogen Phosphorylase”; Archives of Biochemistry and Biophysics, vol. 386, No. 2, Feb. 15, 2001, pp. 179-187.
Klaus Godl, et al.; “An efficient proteomics method to identify the cellular targets of protein kinase inhibitors”; PNAS, vol. 100, No. 26, Dec. 23, 2003; pp. 15434-15439.
Takashi Owa, et al.; “Discovery of Novel Antitumor Sulfonamides Targeting G1 Phase of the Cell Cycle”; Journal of Medical Chemistry, 1999, vol. 42, No. 19, pp. 3789-3799.
Steven P. Gygi, et al.; “Quantitative analysis of complex protein mixtures using isotope-coded affinity tags”; Nature Biotechnology, vol. 17, Oct. 1999, pp. 994-999.
David K Han, et al.; “Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry”; Nature Biotechnology, vol. 19, Oct. 2001, pp. 946-951.
Robert Tonge, et al.; “Validation and development of fluorescence two-dimensional differential gel electrophoresis proteomics technology”; Proteomics 2001, vol. 1, pp. 377-396.
Yoshiya Oda et al.; “Quantitative Chemical Proteomics for Identifying Candidate Drug Targets”; Analytical Chemistry, vol. 75, No. 9, May 1, 2003; pp. 2159-2165.
Adams Michelle
Dickstein & Shapiro LLP
Eisai R & D Management Co. Ltd.
Gakh Yelena G
LandOfFree
Method of analyzing protein structural affinity relationship does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of analyzing protein structural affinity relationship, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of analyzing protein structural affinity relationship will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4287405