Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2004-05-20
2009-06-30
Riley, Jezia (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S005000, C435S007100, C435S007200, C536S023740, C536S024300, C536S026600
Reexamination Certificate
active
07553624
ABSTRACT:
The present invention provides a method of analyzing the physiological function of a target substance by inactivating the physiological function of the target substance, comprising the steps of: (a) binding to the target substance a photoactive compound represented by formula (I):(in the formula, Q is a group for binding this compound with the target substance) to form a composite comprising the target substance and the photoactive compound; and (b) irradiating the obtained composite with light to inactivate the function of the target substance to which the photoactive compound has been bound, or to inactivate the function of the target substance at the site where the photoactive compound has been bound.
REFERENCES:
patent: 4797480 (1989-01-01), Sorbi et al.
patent: 2000-206116 (2000-07-01), None
patent: 2002-531810 (2002-09-01), None
Deerinck, T.J. et al., Fluorescence Photooxidation with Eosin: A Method for High Resolution Immunolocalization and In Situ Hybridization Detection for Light and Electron Microscopy, Aug. 1994, pp. 901-910, The Journal of Cell Biology, vol. 126, No. 4.
Giepmans, B.N.G. et al., The Fluorescent Toolbox for Assessing Protein Location and Function, Apr. 14, 2006, pp. 217-224, www.sciencemag.com, vol. 312.
Yan, P. et al., Fluorophore-Assisted Light Inactivation of Calmodulin Involves Singlet-Oxygen Mediated Cross-Linking and Methionine Oxidation, 2006, pp. 4736-4748, Biochemistry 2006, 45.
Anke et al.,Chromophore-Assisted Laser Inactivation of Cellular Proteins, Methods in Cell Biology, vol. 44, 1994, 715-733.
Jay,Selective Destruction of Protein Function by Chromophore-Assisted Laser Inactivation, Proc. Natl. Acad. Sci., USA, vol. 85, Aug. 1988, 5454-5458.
Surrey, et al.; “Chromophore-assisted light inactivation and self-organization of microtubules and motors”, Proc. Natl. Acad. Sci. USA, vol. 95, pp. 4293-4297, 1998.
Miyawaki Atsushi
Nagai Takeharu
Japan Science & Technology Agency
Morgan Lewis & Bockius
Riley Jezia
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