Method of analyzing physiological function of target substance

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S005000, C435S007100, C435S007200, C536S023740, C536S024300, C536S026600

Reexamination Certificate

active

07553624

ABSTRACT:
The present invention provides a method of analyzing the physiological function of a target substance by inactivating the physiological function of the target substance, comprising the steps of: (a) binding to the target substance a photoactive compound represented by formula (I):(in the formula, Q is a group for binding this compound with the target substance) to form a composite comprising the target substance and the photoactive compound; and (b) irradiating the obtained composite with light to inactivate the function of the target substance to which the photoactive compound has been bound, or to inactivate the function of the target substance at the site where the photoactive compound has been bound.

REFERENCES:
patent: 4797480 (1989-01-01), Sorbi et al.
patent: 2000-206116 (2000-07-01), None
patent: 2002-531810 (2002-09-01), None
Deerinck, T.J. et al., Fluorescence Photooxidation with Eosin: A Method for High Resolution Immunolocalization and In Situ Hybridization Detection for Light and Electron Microscopy, Aug. 1994, pp. 901-910, The Journal of Cell Biology, vol. 126, No. 4.
Giepmans, B.N.G. et al., The Fluorescent Toolbox for Assessing Protein Location and Function, Apr. 14, 2006, pp. 217-224, www.sciencemag.com, vol. 312.
Yan, P. et al., Fluorophore-Assisted Light Inactivation of Calmodulin Involves Singlet-Oxygen Mediated Cross-Linking and Methionine Oxidation, 2006, pp. 4736-4748, Biochemistry 2006, 45.
Anke et al.,Chromophore-Assisted Laser Inactivation of Cellular Proteins, Methods in Cell Biology, vol. 44, 1994, 715-733.
Jay,Selective Destruction of Protein Function by Chromophore-Assisted Laser Inactivation, Proc. Natl. Acad. Sci., USA, vol. 85, Aug. 1988, 5454-5458.
Surrey, et al.; “Chromophore-assisted light inactivation and self-organization of microtubules and motors”, Proc. Natl. Acad. Sci. USA, vol. 95, pp. 4293-4297, 1998.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of analyzing physiological function of target substance does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of analyzing physiological function of target substance, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of analyzing physiological function of target substance will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4059522

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.