Method of analyzing ligand in sample and apparatus for...

Details Method of analyzing ligand in sample and apparatus for... Method of analyzing ligand in sample and apparatus for...

2007-12-25

2007-12-25

Chin, Christopher L. (Department: 1641)

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

C385S129000, C385S130000, C422S051000, C422S082050, C422S082110, C435S006120, C435S287100, C435S288700, C435S808000, C436S164000, C436S165000, C436S518000, C436S524000, C436S525000, C436S805000, C436S817000

Reexamination Certificate

active

10570654

ABSTRACT:
A sample analyzing method capable of high-precision analysis without being affected by vibration and optical design is provided. In the sample analyzing method, a sample containing a ligand is caused to bind to a receptor that can bind specifically to the ligand, and a change caused by binding of the receptor and the ligand is analyzed by measuring frequency characteristics of a surface plasmon resonance angle while applying external vibration to the receptor. The sample analyzing method is useful in the fields of, for example, biology, medicine, pharmacology, agriculture, and the like.

REFERENCES:
patent: 6161437 (2000-12-01), Brennan et al.
patent: 6649361 (2003-11-01), Iwasaki et al.
patent: 2002/0001085 (2002-01-01), Dickopf et al.
patent: 2001-194298 (2001-07-01), None
patent: 2002-530668 (2002-09-01), None
patent: 2003-65947 (2003-03-01), None
patent: 2003-66004 (2003-03-01), None
patent: 2003-75336 (2003-03-01), None
Sota, et al., “Detection of Conformational Changes in an Immobilized Protein Using Surface Plasmon Resonance”, Anal. Chem., 1998, vol. 70, pp. 2019-2024.

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