Method of analyzing 5-hydroxyindoles and catecholamines, and a d

Details Method of analyzing 5-hydroxyindoles and catecholamines, and a d Method of analyzing 5-hydroxyindoles and catecholamines, and a d

1996-06-17

1998-10-20

Soderquist, Arlen

Chemistry: analytical and immunological testing

Nitrogen containing

Amine and quaternary ammonium

436 63, 436 89, 436 91, 436 96, 436106, 436131, 436161, 436164, 436166, 436172, 436174, 422 52, 422 69, 422 70, 422 81, 422 8205, G01N 3348, G01N 2176, G01N 3002

Patent

active

058245596

ABSTRACT:
A method and a device for the analysis of 5-hydroxyindoles or catecholamines with high sensitivity. New chemiluminescence labeling agents, 6-aminomethylphthalhydrazide or 1,2-bis(phthalhydrazino)ethylenediamine, are reacted with 5-hydroxyindoles or catecholamines to form their stable derivatives. The derivatives emit strong luminescence in the presence of an oxidizing agent. In the chemiluminescence detection method, there is extremely low background noise and thus the method enables analysis with high sensitivity. The analysis of 5-hydroxyindoles or catecholamines in a sample is enabled by a method (1), in which each of the above-mentioned components is separated, reacted with said chemiluminescence labeling agent to form its derivative, and then chemiluminescent emitted by the reaction of the derivative with an oxidizing agent is detected, or by another method (2), in which the mixture of 5-hydroxyindoles or catecholamines in a sample is reacted with the chemiluminescence labeling agent to form its derivative mixture, subsequently each derivative is separated, and then chemiluminescent emitted by the reaction of the derivative with an oxidizing agent is detected.

REFERENCES:
patent: 4181650 (1980-01-01), Maier, Jr.
patent: 4419452 (1983-12-01), Imai et al.
patent: 4834918 (1989-05-01), Wulff et al.
Y. Umegae et al. Anal. Chim. Acta 1988, 208, 59-68.
Y. Umegae et al, Chem. Pharm. Bull. 1990, 38, 2293-2285.
J. Ishida et al, Analyst 1991, 116, 301-307.
H. Nohta et al. Anal. Chim. Acta 1992, 267, 137-139.
S. Higashidate et al. Analyst. 1992, 117, 1863-1868.
H. Nohta et al. Anal. Sci. 1994, 10, 5-9.
Z. Pang et al. Fenxi Kexue Xuebao 1994, 10, 53-58.
G.H. Ragab et al. Anal. Chim. Acta 1994, 298, 431-438.
Analyst, Mar. 1991, vol. 116, Spectrofluorimetric Determination of 5-Hydroxyindoles With Benzylamine or 3,4-Dimetoxybenzylamine as a Selective Fluorogenic Reagent,J.Ishida et al. pp. 301-304.
Analytica Chimica Acta 208 (1988) 59-68, 1,2-Diarylethylenediamines as Fluorogenic Reagents for Catecholamines, Yoshihiko Umegae et al. pp. 59-68.
Patent Abstracts of Japan 56-133649 (A), vol. 6, No. 8, Jan. 19, 1982.
Patent Abstracts of Japan 62-190446 (A), vol. 12, No. 43, Feb. 9, 1988.
Biochemische Analytik, "Angewandte Chemilumineszenz", Nachr. Chem. Tech. Lab. 40 (1992) Nr. 5, pp. 547-553.

Affiliated with

Also associated with

Rating

Method of analyzing 5-hydroxyindoles and catecholamines, and a d does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of analyzing 5-hydroxyindoles and catecholamines, and a d, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of analyzing 5-hydroxyindoles and catecholamines, and a d will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-243610