Chemistry: analytical and immunological testing – Oxygen containing – Carbonyl – ether – aldehyde or ketone containing
Reexamination Certificate
2007-12-18
2007-12-18
Wallenhorst, Maureen M. (Department: 1743)
Chemistry: analytical and immunological testing
Oxygen containing
Carbonyl, ether, aldehyde or ketone containing
C436S056000, C436S111000, C436S173000, C436S175000
Reexamination Certificate
active
10675763
ABSTRACT:
A method of identification and quantitative analysis of aldehydes and/or ketones in a sample by mass spectrometry using stable isotope labeled oxime internal standards or stable isotope labeled hydrazone internal standards is provided. Stable isotope labeled oxime internal standards are synthesized by reaction of an authentic sample of aldehydes and/or ketones with a stable isotope labeled alkoxylamine reagent while stable isotope labeled hydrazone internal standards are synthesized by reaction of an authentic sample of aldehydes and/or ketones with a stable isotope labeled alkylhydrazine reagent. A non labeled version of the stable isotope labeled reagent is used to convert aldehydes and/or ketones in the sample to the non labeled version of the stable isotope labeled oxime or hydrazone internal standards.
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Nguyen Duc Tien
Nguyen Hoa Duc
Nguyen Trinh Duc
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