Method of analysis of alcohol by mass spectrometry

Details Method of analysis of alcohol by mass spectrometry Method of analysis of alcohol by mass spectrometry

2003-09-30

2008-10-21

Gakh, Yelena G (Department: 1797)

Chemistry: analytical and immunological testing

Nuclear magnetic resonance, electron spin resonance or other...

C436S024000

Reexamination Certificate

active

07439074

ABSTRACT:
Method of identification and quantitative analysis of alcohol(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said alcohol with a stable isotope labeled reagent, and is added to a sample containing said alcohol. Said alcohol in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said alcohol are made from a plot of ion ratio of said converted alcohol to said internal standard versus alcohol concentration.

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