Method of amphiphatic drug loading in liposomes by ammonium ion

Details Method of amphiphatic drug loading in liposomes by ammonium ion Method of amphiphatic drug loading in liposomes by ammonium ion

1992-12-18

1994-05-31

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 41, 264 43, 264 46, 424710, 4284022, 436829, A61K 3722

Patent

active

053167716

ABSTRACT:
An improved simple, efficient, safe, economical, and fast transmembrane ling procedure for efficient active loading of weak amphiphatic drugs into liposomes using the transmembrane gradient. The resulting liposomes loaded with the amphiphatic drug are stable and safe. A storagable form of loadable liposomes has extended period of stability. The reversed procedure is applicable for sustained release of liposome encapsulated drugs from ammonium liposomes.

REFERENCES:
patent: 5192549 (1993-03-01), Barenolz et al.
patent: 5204112 (1993-04-01), Hope et al.

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