Method of altering the binding specificity of plasma...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C204S554000, C210S758000, C424S176100, C424S177100, C424S810000, C436S506000, C436S825000, C530S390100, C530S390500, C530S402000, C530S427000, C530S868000

Reexamination Certificate

active

07368542

ABSTRACT:
The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium is altered by exposing the protein to an oxidizing agent or an electric current sufficient to alter its binding specificity. A masked protein such as an autoantibody can be recovered from blood or blood products or extracts by oxidizing the protein to change its binding specificity.

REFERENCES:
patent: 4703001 (1987-10-01), Vodian et al.
patent: 4950612 (1990-08-01), Khanna et al.
patent: 5061790 (1991-10-01), Elting et al.
patent: 5939394 (1999-08-01), Fleming et al.
patent: 5980954 (1999-11-01), Bolton
patent: 6660267 (2003-12-01), Carroll
patent: 2004/0101909 (2004-05-01), Lemieux et al.
patent: 2005/0101016 (2005-05-01), McIntyre
patent: WO 2004/111608 (2004-12-01), None
McIntyre, John A., “The appearance and Disappearance of Antiphospholipid Antibodies Subsequent to Oxidation-Reduction Reactions”, appearing in Thrombosis Research, 2004, vol. 114, pp. 579-.
www.ucsfhealth.org/childrens/edu/bottleWeaning.html , provided by UCSF Children's Hospital, Patient Education, Baby Bottle Weaning, 2002-2007.
Ischiropoulus, Harry et al, “Oxidative Stress and Nitration in Neurodegeneration: Cause, effect, or association?”,J. Clin. Invest. 2003 111:pp. 163-169.
Smith, Mark A., et al, “Widespread Peroxynitrite-Mediated Damage in Alzheimer's Disease”.J. Neuroscience, Apr. 15, 1997, 17(8), pp. 2653-2657.
McIntyre, John A., “The Appearance and Disappearance of Antiphospholipid Autoantibodies Subsequent to Oxidation-reduction Reactions”,Thrombosis Research2004, 114, pp. 579-587.
McIntyre, John A., et al, “Autoantibodies Unmasked by Redox Recations”,J. Autoimmun2005; 24, pp. 311-317.
McIntyre, John A., et al “Redox-reactive Autoantibodies: Detection and Physiological Relevance”,Autoimmunity Reviews 2006; 5, pp. 76-83.
Sokol, D.K. et al, “Testing for Antiphospholipid Antibody (aPL) Specificities in Retrospective ‘Normal’ Cerebral Spinal Fluid (CSF)”,Clin Develop. Immunol. 2005; 11: pp. 7-12.
Adams, J. Paige et al, “Molecular Psychology: Roles for the ERK MAP Kinase Cascade in Memory”,Annu. Rev. Pharmacol. Toxicol. 2002, 42, pp. 135-163.
Hindley, Alison et al, “Extracellular Signal Regulated Kinase (ERK)/mitogen Activated Protein Kinase (MAPK)-independent Functions of Raf Kinases”,J. Cell Science, 2002; 115, pp. 1575-1581.
Cheung et al, “Emerging Role for ERK as a Key Regulator of Neuronal Apoptosis”,Science, 2004; 251: pp. 1-3.
Chapman, J. et al, “Antiphospholipid Antibodies Permeablizie and Depolarize Brain Synaptoneurosomes”,Lupus1999; 8: pp. 127-133.
D'Aandrea, PhD, Michael R., “Evidence that immunoglobulin-positive Neurons in Alzheimer's Disease are Dying Via the Classical Antibody-dependent Complement Pathway”,Am. J. Alzheimer's Dis. Other Dimentas2005; 20; pp. 144-150.
Colucci-D'Amato, L. et al, “Chronic-Activation of ERK and Neurodegenerative Diseases”,Bioassays, 2003; 25; pp. 1085-1095.
Robertson and Greaves, Blood Rev 20: 2006, pp. 201-212.
Gallo et al., J. Neurol Sc. 122, 1994, pp. 97-101.
Tanne et al., Curr Rheumat Rep 3, 2001, pp. 286-292.
Jedryka-Goral. Et al. Clin Rheumatol 19, 2000, pp. 306-310.
Mosek et al. Dem. Ger Cog. Disorder 11:, 2000, pp. 36-38.
Oomen et al. Psychiat Res 58, 1995, pp. 83-88.
Gomez-Puerta et al., Rheumatol 44:, 2005, pp. 95-99.
Sokol et al., Nuerology 55: 2000, pp. 1379-1381.
Martinez-Cordero et al., J. Invest Allerg Clin Immunol 7, 1997, pp. 596-601.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of altering the binding specificity of plasma... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of altering the binding specificity of plasma..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of altering the binding specificity of plasma... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2772522

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.