Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Patent
1991-08-05
1993-08-03
Raymond, Richard L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
436 20, 436 63, 436 64, 436 71, 436815, 560196, 564507, C12Q 148
Patent
active
052328376
ABSTRACT:
This invention provides a method of altering the metabolism of sphingolipids in a cell comprising contacting the cell with a fumonisin, or an analog thereof. The invention also provides a method of detecting the consumption of a fumonisin or a fumonisin analog in a subject comprising (A) detecting, in a sample from the subject, the state of the metabolic pathway of sphingolipids and (B) comparing the state of the metabolic pathway to that of a normal subject, the presence of a change in the state of the metabolic pathway indicating the consumption of a fumonisin or a fumonisin analog. Also provided is a method of detecting the presence of a fumonisin or fumonisin analog contamination in a sample from a food or feed comprising detecting a reaction of the metabolic pathway of sphingolipids, the presence of the reaction indicating the presence of a fumonisin or fumonisin analog contamination. Furthermore, novel fumonisin analogs and compositions comprising fumonisins and fumonisin analogs are provided.
REFERENCES:
patent: 5103002 (1992-04-01), Wieland
Merrill et al., Anal. Biochem., vol. 171, pp. 373-381 (1988).
Wang, et al., "Inhibition of Sphingosine Biosynthesis by Fumonisins, Mycotoxins Produced by Fusarium Moniliforme, Environmental Pathology and Toxicology" 7164-7165 (1991), abstract presented at Federation of American Societies for Experimental Biology, Atlanta, Ga., Apr., 1991.
Merrill, Alfred H., Jr., "Cell Regulation by Sphingosine and More Complex Sphingolipids," Journal of Bioenergetics and Biomembranes 23:83-104 (1991).
"Fumonisins: A Current Perspective View and a View to the Future," various papers on fumonisins presented at a meeting (Apr. 1991).
Norred et al., "In Vitro Toxicology of Fumonisin and F. moniliforme Toxins and the Mechanistic Implications," presented at Fumonisins: A Current Perspective and a View to the Future, meeting (Apr. 1991).
Bottini, et al., "Characterization of a Phytotoxic Fraction from Alternaria Alternate F. SP. Lycopersici," Tetrahedron Letters 22:2723-2726 (1981).
Liotta Dennis C.
Merrill, Jr. Alfred H.
Riley Ronald T.
Wang Elaine W.
Emory University
Rand Scott C.
Raymond Richard L.
The United States of America as represented by the Secretary of
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