Method of alleviating AIDS symptoms and compositions therefor

Details Method of alleviating AIDS symptoms and compositions therefor Method of alleviating AIDS symptoms and compositions therefor

1990-06-20

1992-12-29

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546105, C07D21908, A61K 31395

Patent

active

051751720

ABSTRACT:
There are provided pharmaceutical compositions and methods of utilizing them for the elevation of T.sub.4 lymphocytes levels in patients having subnormal levels thereof reducing the level of opportunistic infections in AIDS patients as well as, usually, P.sub.24 levels and also for inhibiting the activity of the HIV virus in patients which are HIV seropositive but may not exhibit AIDS symptoms, which comprise, as active constituent an effective amount of a compound selected from the group consisting of 9-amino-1,2,3,4-tetrahydroacridine and the acid addition salts thereof with pharmaceutically acceptable acids. There are also provided, for the same purpose chemical derivatives of 9-amino-1,2,3,4-tetrahydroacridine which are capable of degradation by human stomach acids, other gastric fluids or intestinal enzymes to 9-amino-1,2,3,4-tetrahydroacridine and have the formula 9-N(Q)-1,2,3,4-tetrahydroacridine, wherein Q is <(A.B) where A and B are the same or different and are biologically labile groups. Further included are analogues of the foregoing compounds which carry a substituent in the homoaromatic ring.

REFERENCES:
patent: 4851536 (1989-07-01), Skotnicki et al.
Chemical & Engineering News, vol. 67, No. 26, pp. 7-16 (1989).
R. Faure, J. Chim. Phys. Chim Biol. 78 (6) (1981) 527.
M. E. Konshin Khim, Pharm. Zhur. 5(11) (1971) 10-12.
S. K. Baveha, Ind. J. Pharm. Sci. 48 (1981) 23-25.

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