Method of administration of insulin

Details Method of administration of insulin Method of administration of insulin

1993-01-29

1994-11-15

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 4, A61K 3726, A61K 3718, A61K 3700

Patent

active

053648382

ABSTRACT:
A method for treating a patient suffering from diabetes mellitus and a programmed, portable, hand-held device and formulations used in such treatment methodology is disclosed. The programmed device is loaded with a container which includes a formulation comprised of insulin dispersed in a suitable propellant such as a low boiling point propellant. The container may be completely sealed and may be punctured on insertion in the device but preferably includes a single valve which can be opened to release insulin forced from the container by the propellant. A valve for releasing formulation is controlled by an electronic means for opening the valve in response to a measured threshold of airflow which airflow is measured by an airflow detection means positioned between the valve and a mouthpiece. Insulin is administered when the patient inspiratory flow exceeds a preset threshold. The airflow is measured and when a threshold amount of airflow is achieved, the valve opening means is actuated and a controlled amount of insulin is released from the container. The device includes a microprocessor connected to the means for measuring airflow and the means for opening the valve. The microprocessor is programmed to control the amount of insulin released, based on the particular needs of the patient. The device is electronically connectable to a device which measures serum glucose level and can adjust insulin release amounts based of measured glucose levels.

REFERENCES:
patent: 5011678 (1991-04-01), Wang et al.
Laube et al, J. Aerosol Med., vol. 4(3) p. 286, 1991.
Wigley et al., Diabetes, vol. 20 No. 8, pp. 552-556, 1971
Kohler, Lung:Suppl, pp. 677-684, 1990.
Laube et al., Jama, vol. 269, No. 16, Apr. 28, 1993, pp. 2106-2109.

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