Surgery – Respiratory method or device – Means for mixing treating agent with respiratory gas
Patent
1992-01-10
1994-06-14
Burr, Edgar S.
Surgery
Respiratory method or device
Means for mixing treating agent with respiratory gas
12820024, 12820014, 12820021, 12820023, A61M 1500, A61M 1610, A61M 1100, A62B 700
Patent
active
053200942
ABSTRACT:
A method of delivering a protein, in particular insulin, to the lungs. The method is characterized in that an aerosolized mist of small particles is produced in an associated medicament delivery chamber, the distance from the chamber to the patient's mouth is set to slow the speed of aerosol particles entering the mouth and the flow rate through the chamber is regulated to a low rate of less than about 30 liters per minute. It has been found that administering insulin in accordance with the invention may advantageously produce a penetration of medication into the lungs of about 90%.
REFERENCES:
patent: 2788784 (1967-04-01), Birch et al.
patent: 2944546 (1960-07-01), Ziherl et al.
patent: 4119097 (1978-10-01), Spector
patent: 4484577 (1984-11-01), Sackner et al.
patent: 4534343 (1985-08-01), Nowacki et al.
patent: 4612929 (1986-09-01), Boiarski et al.
patent: 4624251 (1986-11-01), Miller
patent: 4635627 (1987-01-01), Gam
patent: 4677975 (1987-07-01), Edgar et al.
patent: 4790305 (1988-12-01), Zoltan
patent: 4796614 (1989-01-01), Nowacki et al.
patent: 4829996 (1989-05-01), Noakes et al.
patent: 4929852 (1990-05-01), Zoltan et al.
patent: 5027806 (1991-07-01), Zoltan et al.
Harrison & Cantab; Insulin in Alcoholic Solution by the Mouth; The British Medical Journal; Dec. 22, 1923 pp. 1204-1205.
Shichiri et al; Increased Intestinal Absorbtion of Insulin in a Micellar Solution; Water-in-Oil-in-Water Insulin Micelles; First Department of Medicine; Oct. 20, 1977; pp. 175-183.
Newman et al; Deposition of Pressurised Aerosols in the Human Respiratory Tract; Department of Medical Physics; 1981; pp. 52-55.
Wigley, et al-Insulin Across Respiratory Mucosae by Aerosol Delivery-Diabetes, vol. 20, No. 8, Aug., 1971, pp. 552-556.
Elliott et al-Parental Absorption of Insulin from the Lung in Diabetic Children-Aust. Paediatr. J. (1987), pp. 293-297.
Adams, III G. Kenneth
Georgopoulos Angeliki
Laube Beth L.
Asher Kimberly L.
Burr Edgar S.
The Johns Hopkins University
LandOfFree
Method of administering insulin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of administering insulin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of administering insulin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1241106