Method of administering human pluripotent hematopoietic colony s

Details Method of administering human pluripotent hematopoietic colony s Method of administering human pluripotent hematopoietic colony s

1995-06-07

1997-09-02

Jagannathan, Vasu S.

Drug, bio-affecting and body treating compositions

Lymphokine

514 2, 514 8, A61K 3818, A61K 3819

Patent

active

056628951

ABSTRACT:
Highly purified Pluripotent hematopoietic colony-stimulating factor (pluripotent CSF), a glycoprotein (MW 19,600) constitutively produced by human tumor cells has been highly purified from low serum-containing conditioned medium to apparant homogeneity. Pluripotent CSF supports the growth of human mixed colonies (CFU-GEMM), granulocyte-macrophage colonies (CFU-GM), early erythroid colonies (BFU-E) and induces differentiation of human leukemic cells. The specific activity of the purified pluripotent CSF in the CFU-GM assay is 1.5.times.10.sup.8 U/mg protein.

REFERENCES:
patent: 4833127 (1989-05-01), Ono et al.
Callard et al. 1994. The Cytokine Facts Book, Academic Press, Harcourt Brace & Co., London, pp. 134-138.
Van Brunt. 1989. Bio/Technology 7:15-16.

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