Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Patent
1996-01-05
1998-03-10
Bawa, Raj
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
424 46, 514255, 514851, A61K 912
Patent
active
057258422
ABSTRACT:
Methods are disclosed for removing retained mucus secretions from the lungs of a human subject. The method includes (1) generating an aerosol suspension of respirable solid, dry particulate amiloride, and (2) delivering by inhalation the aerosol suspension to the respiratory system of the subject. The solid particulate amiloride is comprised of particles of about 1 to 5 microns and is free of liquid amiloride particles. The aerosol suspension of respirable solid particulate amiloride is administered in an amount sufficient to achieve concentrations of amiloride on the airway surfaces of from about 10.sup.-7 to 10.sup.-3 Moles/liter. As a result of the treatment, the secretions are hydrated and more easily transported from the lung via mucociliary action. Methods are also disclosed for the treatment of cystic fibrosis in humans.
REFERENCES:
patent: 3313813 (1967-04-01), Cragoe, Jr.
patent: 4501729 (1985-02-01), Boucher et al.
patent: 5100647 (1992-03-01), Agus et al.
patent: 5162348 (1992-11-01), Glass
patent: 5292498 (1994-03-01), Boucher, Jr.
I.M. Bowler, Nebulised amiloride in respiratory exacerbations of cystic fibrosis: a randomised controlled trial, Archives of Disease in Childhood 73, 427-30 (1995).
M. Knowles et al., New Eng. J. Med. 322, No. 17, 1189-1194 (1990).
Boucher, Jr. Richard C.
Knowles Michael R.
Bawa Raj
The University of North Carolina at Chapel Hill
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