Method of administering a microgranular preparation to the intes

Details Method of administering a microgranular preparation to the intes Method of administering a microgranular preparation to the intes

1994-07-26

1997-01-28

Rollins, John W.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 941, 424 943, 424 9461, 424 9463, 424438, 424458, 424460, 424490, 424646, 424648, 424643, 514 52, 514963, 514965, A61K 3854, A61K 3848, A61K 950, A61K 3300

Patent

active

055975640

ABSTRACT:
A microgranular preparation having a core of biologically active material that is encapsulated by a water soluble film that is covered by an enteric coating of either an alkali soluble, acid insoluble polymer or a high molecular weight polymer whose structure is substituted with or contains windows of fatty acids or other material capable of being solubilized by intestinal juices. Useful for protecting pH sensitive and other biologically active materials from inactivation or contact with the stomach or rumen, and releasing the same in active form in the intestinal tract, particularly the duodenum.

REFERENCES:
patent: 3656997 (1972-04-01), Cordes
patent: 3789117 (1974-01-01), Tsujino
patent: 3803304 (1974-04-01), Antonides
patent: 4230687 (1980-10-01), Sair et al.
patent: 4332790 (1982-06-01), Sozzi et al.
patent: 4447412 (1984-05-01), Bilton
patent: 5356625 (1994-10-01), Ying
Pointner, H. and Flegel, U., "Treatment of Exocrine Pancreatic Insufficiency With Fungal Lipase, " English Abstract, Nov. 1975.
Pancreatic Extracts, The Lancet, No. 8028, pp. 73-74, Jul. 9, 1977.
Beck, V. K., "Fermentsubstitution bei Maldigestion", Zeitschrift fur Gastroenterologie, pp. 171-188.
International search report for prior application No. PCT/AU87/00270.

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