Method of acylating maytansinol with chiral amino acids

Details Method of acylating maytansinol with chiral amino acids Method of acylating maytansinol with chiral amino acids

2006-08-08

2009-10-06

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

07598375

ABSTRACT:
This invention provides a method for making maytansinoids having a chiral amino acid side chain, such as DM1 and DM4 that are used to treat cancer. According to this method, the side chain may be added with little epimerization of the amino acid chiral center.

REFERENCES:
patent: 4260609 (1981-04-01), Baldwin et al.
patent: 6333410 (2001-12-01), Chari et al.
patent: 7301019 (2007-11-01), Widdison et al.
patent: WO 03/074551 (2003-12-01), None
patent: WO 2006/078809 (2006-07-01), None

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