Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1982-11-08
1985-07-30
Rosen, Sam
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
128334R, 424 95, A61K 3170, A61B 1704
Patent
active
045321345
ABSTRACT:
The method of achieving hemostasis, inhibiting fibroplasia, and promoting tissue regeneration is described wherein a chitosan solution, or water-soluble chitosan in various solid forms is placed in contact with the tissue wound. The chitosan forms a coagulum which prevents bleeding and negates the formation of a blood clot thereby preventing the formation of fibrin strands. The prevention of the formation of fibrin strands prevents the proliferation of fibroblasts and the synthesis of collagen thereby allowing the promotion of normal tissue regeneration. The process described hereinabove results in wound healing with minimal scar formation. The use of chitosan in grafts is contemplated as well as the use of polyglucosamine in wound healing.
REFERENCES:
patent: 3632754 (1972-01-01), Balassa
patent: 3911116 (1975-10-01), Balassa
Balassa et al., Chem. Abst., vol. 91, (1979), p. 13962u.
Prudden et al., Chem. Abst., vol. 73, (1970), p. 43828a.
Prudden et al., The Amer. J. of Surgery, vol. 119, May 1970, pp. 560-564.
Malette William G.
Quigley Herbert J.
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