Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1985-05-28
1989-10-10
Hill, Jr., Robert J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
43524027, 436512, 436519, 436548, 436804, 436813, 530387, 530388, 530808, 935104, 935110, G01N 33574, G01N 33577
Patent
active
048731889
ABSTRACT:
The present invention is concerned with two novel monoclonal antibodies which define carbohydrate antigens associated with human non-small cell lung carcinomas ("NSCLC") and certain other human carcinomas. The antibodies bind to normal human cells to a much lesser degree than to tumor cells. The antibodies find use in diagnostic methods such as the detection of malignant cells associated with NSCLC and in therapeutic methods. The invention also comprises a method for determining the presence of a malignant condition in the lung of a subject. The method involves examining tissue from the subject for the presence of antigens which are Le.sup.x or Le.sup.y antigen or which have the characteristics of Le.sup.y and Le.sup.x.
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Brown Joseph P.
Hellstrom Ingegerd
Hellstrom Karl E.
Horn Diane
Linsley Peter
Hill Jr. Robert J.
Oncogen
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