Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Patent
1995-12-18
1997-01-28
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
424 9321, 424 931, 424 9371, 4241841, 4242781, A61K 3900, A61K 3822, A61K 3528
Patent
active
055975631
ABSTRACT:
A method for inducing antigen-specific immune tolerance by depletion of resident thymic antigen presenting cells (APCs) and re-population of thymus with new APCs containing the antigen for tolerance is described.
REFERENCES:
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Mixed Bone Marrow Reconstitution as an Approach to Xenograft Tolerance Sundt & Sachs, National Cancer Institute, pp. 237-246.
Improved Results With Combined Donor-Specific Transfusion (DST) and Sequential Therapy Protocol Salvatierra, et al., Transplantation Proceedings, No. 1, 23:1024-1026, Feb. 1991.
Olvwole et al (1988) Mechanism of Immunologic . . . Transplantation 46:352-358.
Knight et al (1986) Sensitivity of Veiles (Dendrite) . . . Transplantation 41:96-100.
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Beschorner et al (1991, Nov.) Enhancement of Thymic Recorez . . . Transplantation 52:879-884.
Lagaais, E. L. et al., New Engl. J. Med. 321:701-5 (Sep. 14, 1989), "Effect of one-HLA-DR-Antigen-Matched and Completely HLA-DR-Mismatched Blood Transfusions on Survival of Heart and Kidney Allografts.".
Posselt, A. M., et al., Science 249:1293-1295 (14 Sep. 1990) "Induction of Donor-Specific Unresponsiveness by Intrathymic Islet Transplantation.".
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