Method for visualizing the base sequence of nucleic acid polymer

Details Method for visualizing the base sequence of nucleic acid polymer Method for visualizing the base sequence of nucleic acid polymer

1989-07-24

1992-04-21

Burgess Yarbrough, Amelia

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 91, 435810, 250306, 250307, 250311, 436501, 536 27, 935 77, 935 86, 935 87, 935 88, C12Q 168

Patent

active

051067293

ABSTRACT:
A method for determining and visualizing the base sequence of nucleic acid olymers, especially DNA and RNA, with a scanning probe microscope having a tip, the method including replacing the oxygen in the nucleic acid polymer with sulfur, complexing the sulfur with a metal such as mercury, and passing the tip over the complexed polymer in a scanning path to measure the potential and record the difference in electrical conductivity at preselected increments along the scanning path.

REFERENCES:
patent: 4711955 (1987-12-01), Ward et al.
Lindsay et al. (1989) Science, vol. 244, pp. 1063-1064.

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