Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1997-04-29
2000-01-04
Weber, Jon P.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
4351731, 435 2, C12N 1300, A01N 102
Patent
active
060108908
ABSTRACT:
The present invention provides methods for reducing the level of infectious virus contained in red blood cell compositions. The methods comprise the steps of contacting the composition with a photosensitizer formulated in a liposome carrier, and exposing the composition to light at a sufficient wavelength, dose and duration to reduce the level of infectious virus contained in the composition. In the methods of the present invention, a quencher, either alone or formulated in a liposome carrier, also may be added to the red blood cell composition before application of light. The present invention also provides compositions containing photosensitizers formulated in specific liposome carriers, as well as quenchers formulated in liposome carriers, for use in the methods of the present invention.
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Ben-Hur Ehud
Zuk Maria M.
New York Blood Center Inc.
Weber Jon P.
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