Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1986-07-28
1989-07-25
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536114, 536123, 435101, 435104, A61K 31715, C07B 3700
Patent
active
048513938
ABSTRACT:
A method for utilizing a purified exocellular polysaccharide, Zooglan, produced by Zoogloea ramigera, as a viscosity modifier, gellant, drag reducing agent, dispersant, flocculant, or emulsifying agent, wherein the properties of the polymer are dependent on, and can therefore be controlled by varying, the pH, the concentration of polymer, the ionic strength of the solution, and the processing parameters such as mechanical shear.
The overall conformation of Zooglan, which is responsible for its functional properties, can be manipulated with pH and/or ionic strength of the solution. For example, the intrinsic viscosity of Zooglan (estimated m.w.=2.times.10.sup.7) can vary from 16 to 170 dl/g in aqueous solution as a function of pH between 2-9 and salt concentration between 0 and 1M KCl. Zooglan is a polyelectrolyte above pH 2. The Zooglan chain is relatively stiff, with a stiffness parameter of 0.02. Zooglan solutions at a concentration above 0.01 g/dl are viscoelastic and pseudoplastic with thixotropic hysteresis and yield stress. The effects of shear rate and shearing time on the viscosity of Zooglan solutions are recoverable or non-recoverable based on solution conditions. Zooglan can form a gel or network by chain entanglement.
This wide range of functional properties makes Zooglan an effective molecule for utilization in a variety of products such as pharmaceuticals, personal care and cosmetic products, food, paint and ink, textiles and paper products.
REFERENCES:
patent: 3406114 (1968-10-01), Goren
patent: 3849395 (1974-11-01), Moirano
patent: 4529797 (1985-07-01), Peik et al.
patent: 4567140 (1986-01-01), Voelskow et al.
patent: 4638059 (1987-01-01), Sutherland
patent: 4647657 (1987-03-01), Wan
patent: 4752580 (1988-06-01), Downs
patent: 4758356 (1988-07-01), Downs
Norberg, A. et al., Applied and Environmental Microbiology Nov. 1982 44(5): 1231-1237.
Stauffer K. et al., Journal of Food Science 45: 946-952 (1980).
Nakamura T. et al., "Solution Properties of Polysaccharide Flocculant Produced by Z. ramigera 115" In Press.
Nakamura T. et al., "Hydrodynamic Volume and Chain Flexibility of Exocelulke Polysacchride Produced by Z. ramigera 115" In Press.
Sinsky A. et al., Biotechnology in Food Processing pp. 73-114 (1986).
Easson, Jr., D. et al., "Engineering of Biopolymer Flocculants" a Recombinant DNA Approach (1986).
Easson Jr. Donald D.
Nakamura Tetsuhisa
Pradipasena Pasawadee
Rha ChoKyun
Sinskey Anthony J.
Carson Nancy S.
Griffin Ronald W.
Massachusetts Institute of Technology
LandOfFree
Method for utilizing an exocellular polysaccharide isolated from does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for utilizing an exocellular polysaccharide isolated from, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for utilizing an exocellular polysaccharide isolated from will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2358272