Method for using verapamil for treating stroke

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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A61K 31135

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046543724

ABSTRACT:
The present invention is a method of use for the treatment of stroke with one of diltiazem, verapamil, or nifedipine.

REFERENCES:
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A. Kappert, "The Clinical Value of Calcium Entry Blockers in Circulatory Disorders, Effect of Flunarizine in Cerebro-Vascular and Peripheral Vascular Diseases", Inter. Angio., 3, 1984, pp. 43-51.
D. P. Reedy, et al., "Effects of Verapamil on Acute Focal Cerebral Ischemia", in Neurosurgery, vol. 12, No. 3, 1983, pp. 272-276.
J. K. Deshpande and T. Wielock, "Amelioration of Ischemic Brain Damage by Postischemic Treatment with Flunarizine, Neurological Research, 1985, vol. 7, Mar., pp. 27-29.
J. R. Berger, et al., "Calcium Channel Blocker: Trial in Global Brain Ischemia," Neurology, p. 182, 33 [Suppl. 2] Apr. 1983.
A. I. Faden, et al., "Evaluation of the Calcium Channel Antagonist Nimodipine in Experimental Spinal Chord Ischemis," J. Neurosurg. vol. 60, Apr., 1984, pp. 796-799.
P. A. Steen, et al., "Nimodipine Improves Cerebral Blood Flow and Neurologic Recovery After Complete Cerebral Ischemia in the Dog," Journal of Cerebral Blood Flow and Metabolism, 3:38-43, 1983.
A. Wauguier, et al., "Calcium Entry Blockers as Cerebral Protecting Agents: Comparative Activity in Tests of Hypoxia and Hyperexcitability," Japan J. Pharmacol., 38, pp. 1-7 (1985).

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