Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Patent
1990-05-25
1991-11-19
Lee, Lester L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
525 5411, 521 53, 521 61, 521 62, 521 63, 521 64, A61K 3702, C07K 500
Patent
active
050667840
ABSTRACT:
A substrate comprises a porous polymeric material having a porosity of at least 75% and comprising pores having a diameter within the range 1 to 100 .mu.m and being interconnected by a plurality of holes, and a gel or material adapted in use to form a gel which gel or pre-gel materials is contained and retained within the pores of the polymeric material and is adapted in use to interact with a reactive species and can be made by depositing and retaining the gel or a material adapted in use to form the gel within the pores of the porous polymeric material. The high porosity of the porous polymeric material in combination with the retention of the gel within the pores permit high loading capacities, particularly in the area of peptide synthesis to be achieved. The substrate can be employed in chemical synthesis, chromatography techniques, ion exchange and separation techniques.
REFERENCES:
patent: 4965289 (1990-10-01), Sherrington et al.
CA 79: 66797 c (1973): Losse, A., "Participation of Macroporous Resins in Solid Phase Peptide Synthesis".
CA 105:153511 d (1985): Epton et al., "Polymer-Supported Biopolymer Synthesis: J. Ultra High Load . . . ".
CA 97:216701e (1982): Epton et al., "Polymer-Supported Biopolymer Synthesis. 2. Phenolic . . . ".
Sherrington David C.
Small Philip W.
Celsa Bennett
Lee Lester L.
Unilever Patent Holdings B.V.
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