Method for using phagocytic particles and ATP receptors to...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

Reexamination Certificate

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C424S450000, C424S278100, C424S093730, C428S402200

Reexamination Certificate

active

07037500

ABSTRACT:
This invention provides methods of delivering an antigen to an Class I or Class II MHC receptors to induce immunity against the antigen in a subject having a disease. This invention also provides methods of delivering an antigen to an Class II or class I MHC receptor to supress immunity against the antigen in a subject having a disease.

REFERENCES:
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Buckner, F.S., et al. (1997) “Trypanosoma cruzi infection does not impair major histocompatibility complex class I presentation of antigen to cytotoxic T lymphocytes”,Eur J Immunol.,27(10):2541-2548 (Exhibit I).
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Zambon, A., et al. (1994) “Role of extracellular ATP in cell-mediated cytotoxicity: a study with ATP-sensitive and ATP-resistant macrophages”,Cell Immunol.,156(2):458-467 (Exhibit 9).
Koppelman, B., et al., Evidence for peptide transport across microsomal membranes. Proceedings of the National Academy of Sciences, USA, May 1992, vol. 89, pp. 3908-3912 (Exhibit 1).
Ben-Shahar, S., et al., Production of Specific Major Histocompatibility Complex Class-I-Restricted Epitope by Ubiquitin-Dependent Degradation of Modified Ovalbumin in Lymphocyte Lysate. The Journal of Biological Chemistry, Aug. 22, 1997, vol. 272, No. 34, pp. 21060-21066 (Exhibit 2); and.
Thomas, C., et al., Human Immunodeficiency Virus-1 env Impairs Fcgamma Receptor Mediated Phagocytosis Via a Cyclic Adenosine Monophosphate-Dependent Mechanism. Blood. Nov. 1, 1997, vol. 90, No. 9, pp. 3760-3765 (Exhibit 3).

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