Method for using m-trifluoromethylphenyl-piperidines

Details Method for using m-trifluoromethylphenyl-piperidines Method for using m-trifluoromethylphenyl-piperidines

1977-05-12

1981-03-31

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546192, 546222, 546216, 546346, 546226, 546227, A61K 31445, C07D21118

Patent

active

042593379

ABSTRACT:
Novel m-trifluoromethylphenyl-piperidines of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, branched or straight chain alkyl of 1 to 5 carbon atoms, alkenyl of 3 to 5 carbon atoms, alkynyl of 3 to 5 carbon atoms and phenyl alkyl of 1 to 3 alkyl carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having antidepressive, anorexigenic and antiparkinsonian activity and their preparation and novel intermediates formed therein.

REFERENCES:
patent: 2891066 (1959-06-01), Parcell
Yale, "Journal of Medicinal and Pharmaceutical Chemistry," vol. 1, No. 2, (1959), pp. 121-133.
Burger, Medicinal Chemistry, Third Ed., Wiley-Interscience Publishers, Inc., New York, pp. 1433-1477, (1970).
McElvain et al., "J. Am. Chem. Soc.," vol. 55, pp. 4625-4629, (1933).
Julia et al., "Bull. Soc. Chim. France," (1968), No. 3, pp. 987-1012.
Iselin et al., "Helv. Chimica Acta," vol. 37, pp. 178-184, (1954).
Fuller et al., "Arch. Int. Pharmacodyn.," vol. 214, pp. 263-270, (1975).

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