Liquid purification or separation – Processes – Separating
Patent
1999-02-22
2000-11-28
Kim, John
Liquid purification or separation
Processes
Separating
210739, 210786, 210787, 210789, 435 2, 436523, 436531, 436532, 494 37, B01D 2126, G01N 33537
Patent
active
061531138
ABSTRACT:
A system and method are disclosed for separating particles having different sedimentation velocities. The system includes a container containing a binding substance including first particles and ligands attached to the first particles. When the binding substance is mixed with a liquid carrying at least second and third particles, the ligands bind the first and second particles together to form groups of bound particles. The groups of bound particles are separated from the third particles in a fluid chamber configured to be mounted on a centrifuge rotor. One of the disclosed methods includes forming a saturated fluidized bed of particles to retain the particles groups in the fluid chamber. Another of the disclosed methods includes removing at least some of the first particles after the binding substance is mixed with the liquid carrying second and third particles.
REFERENCES:
patent: 2616619 (1952-11-01), MacLeod
patent: 3825175 (1974-07-01), Sartory
patent: 4035316 (1977-07-01), Yen et al.
patent: 4091989 (1978-05-01), Schlutz
patent: 4146172 (1979-03-01), Cullis et al.
patent: 4187979 (1980-02-01), Cullis et al.
patent: 4190563 (1980-02-01), Bosley et al.
patent: 4239729 (1980-12-01), Hasegawa et al.
patent: 4268393 (1981-05-01), Persidsky et al.
patent: 4269718 (1981-05-01), Persidsky
patent: 4316576 (1982-02-01), Cullis et al.
patent: 4322298 (1982-03-01), Perisdsky
patent: 4350283 (1982-09-01), Leonian
patent: 4415665 (1983-11-01), Mosbach et al.
patent: 4416654 (1983-11-01), Schoendorfer et al.
patent: 4425112 (1984-01-01), Ito
patent: 4464167 (1984-08-01), Schoendorfer et al.
patent: 4540407 (1985-09-01), Dunn
patent: 4624923 (1986-11-01), Margel
patent: 4675117 (1987-06-01), Neumann et al.
patent: 4680025 (1987-07-01), Kruger et al.
patent: 4695553 (1987-09-01), Wardlaw et al.
patent: 4701267 (1987-10-01), Watanabe et al.
patent: 4708710 (1987-11-01), Dunn, Jr.
patent: 4708712 (1987-11-01), Mulzet
patent: 4710472 (1987-12-01), Saur et al.
patent: 4752563 (1988-06-01), Kortright et al.
patent: 4783336 (1988-11-01), Margel et al.
patent: 4798579 (1989-01-01), Penhasi
patent: 4808151 (1989-02-01), Dunn, Jr. et al.
patent: 4851126 (1989-07-01), Schoendorfer
patent: 4885137 (1989-12-01), Lork
patent: 4927749 (1990-05-01), Dorn
patent: 4935147 (1990-06-01), Ullman et al.
patent: 4936820 (1990-06-01), Dennehey et al.
patent: 4936998 (1990-06-01), Nishimura et al.
patent: 4939081 (1990-07-01), Figdor et al.
patent: 4939087 (1990-07-01), Van Wie et al.
patent: 5078671 (1992-01-01), Dennehey et al.
patent: 5089146 (1992-02-01), Carmen et al.
patent: 5100564 (1992-03-01), Pall et al.
patent: 5116724 (1992-05-01), Delaage et al.
patent: 5192553 (1993-03-01), Boyse et al.
patent: 5198334 (1993-03-01), Leung
patent: 5213970 (1993-05-01), Lopez-Berestein et al.
patent: 5224921 (1993-07-01), Dennehey et al.
patent: 5225353 (1993-07-01), Berenson et al.
patent: 5229012 (1993-07-01), Pall et al.
patent: 5238812 (1993-08-01), Coulter et al.
patent: 5246829 (1993-09-01), Delaage et al.
patent: 5282982 (1994-02-01), Wells
patent: 5298171 (1994-03-01), Biesel
patent: 5316666 (1994-05-01), Brown et al.
patent: 5316667 (1994-05-01), Brown et al.
patent: 5348739 (1994-09-01), Hellstrand et al.
patent: 5360542 (1994-11-01), Williamson, IV et al.
patent: 5362291 (1994-11-01), Williamson, IV
patent: 5370802 (1994-12-01), Brown
patent: 5397479 (1995-03-01), Kass et al.
patent: 5409813 (1995-04-01), Schwartz
patent: 5429802 (1995-07-01), Hagiwara et al.
patent: 5432054 (1995-07-01), Saunders et al.
patent: 5474687 (1995-12-01), Van Vlasselaer
patent: 5501795 (1996-03-01), Pall et al.
patent: 5512453 (1996-04-01), Stevenson
patent: 5529691 (1996-06-01), Brown
patent: 5541107 (1996-07-01), Naughton et al.
patent: 5547591 (1996-08-01), Hagihara et al.
patent: 5549834 (1996-08-01), Brown
patent: 5576185 (1996-11-01), Coulter et al.
patent: 5580465 (1996-12-01), Pall et al.
patent: 5580781 (1996-12-01), Naughton et al.
patent: 5587070 (1996-12-01), Pall et al.
patent: 5607830 (1997-03-01), Biesel et al.
patent: 5614106 (1997-03-01), Payrat et al.
patent: 5622819 (1997-04-01), Herman
patent: 5627029 (1997-05-01), Houseal et al.
patent: 5629147 (1997-05-01), Asgari et al.
patent: 5635387 (1997-06-01), Fei et al.
patent: 5639376 (1997-06-01), Lee et al.
patent: 5641414 (1997-06-01), Brown
patent: 5641622 (1997-06-01), Lake et al.
patent: 5643741 (1997-07-01), Tsukamoto et al.
patent: 5643786 (1997-07-01), Cohen et al.
patent: 5656163 (1997-08-01), Brown
patent: 5663051 (1997-09-01), Vlasselaer
patent: 5665557 (1997-09-01), Murray et al.
patent: 5672346 (1997-09-01), Srour et al.
patent: 5674173 (1997-10-01), Hlavinka et al.
patent: 5677136 (1997-10-01), Simmons et al.
patent: 5677139 (1997-10-01), Johnson et al.
patent: 5681559 (1997-10-01), DiGiusto et al.
patent: 5702823 (1997-12-01), Forrestal et al.
patent: 5722926 (1998-03-01), Hlavinka et al.
patent: 5728378 (1998-03-01), Hellstrand et al.
patent: 5906570 (1999-05-01), Langley et al.
patent: 5913768 (1999-06-01), Langley et al.
patent: 5939319 (1999-08-01), Hlavinka et al.
D.G. Walton et al., Creation of Stable Poly(ethlene oxide) Surfaces on Poly(methl methacrylate) Using Blends of Branched and Linear Polymers; Macromolecules 30:6947-6956 (1997).
Hydrophilic polymer surface prepared with branched additive; C&EN Nov. 17, 1997 p. 30.
Maxim D. Persidsky et al., Separation of Platelet-rich Plasma by Modified Centrifugal Elutriation; Journal of Clinical Apheresis 1:18-24 (1982).
John F. Jemionek et al., Special Techniques for the Separation of Hemopoietic Cells, Current Methodology in Experimental Hematology, 1984, pp. 12-16.
J. Freedman et al., White Cell Depletion of Red Cell and Pooled Random-Donor Platelet Concentrates by Filtration and Residual Lymphocyte Subset Analysis, Transfusion, 1991, vol. 31, No. 5, pp. 433-440.
Nancy M. Heddle et al., The Role of the Plasma from Platelet Concentrates in Transfusion Reactions, The New England Journal of Medicine, vol. 331, No. 10, Sep. 8, 1994, pp. 625-628, 670 and 671.
A. Bruil et al., Asymmetric Membrane Filters for the Removal of Leukocytes From Blood, Journal of Biomed. Materials Research, vol. 25, 1459-1480, 1991.
Sunny Dzik, Leukodepletion Blood Filters: Filter Design and Mechanisms of Leukocyte Removal, Transfusion Medicine Reviews, vol. VII, No. 2, Apr. 1993, pp. 65-77.
Bernard J. Van Wie et al., The Effect of Hematocrit and Recycle on Cell Separations, Plasma Ther. Transfus. Technol. 1986; 7:373-388.
P.D. Drumheller et al., The Effects of RPM and Recycle on Separation Efficiency in a Clinical Blood Cell Centrifuge, Journal of Biomechanical Engineering, Nov. 1987, vol. 109, pp. 324-329.
R.J. Oxford et al., Monitoring and Automated Optimization of a Cell Centrifuge, IEEE/Eighth Annual Conference of the Engineering in Medicine and Biology Society, pp. 925-927. (undated).
R.J. Oxford et al., Interface Dynamics in a Centrifugal Cell Separator, Transfusion, Nov.-Dec., 1988, vol. 28, Nov. 6, pp. 588-592.
A. Tulp et al., A Separation Chamber to Sort Cells and Cell Organelles by Weak Physical Forces, V.A. Sector-Shaped Chamber and Its Application to the Separation of Peripheral Blood Cells, Journal of Immunological Methods 69 (1984), pp. 281-295.
Robert J. Grabske, Separating Cell Populations by Elutriation, pp. 1-8 (undated).
Carl G. Figdor et al., Theory and Practice of Centrifugal Elutriation (CE) Factors Influencing the Separation of Human Blood Cells, Cell Biophysics 5, 105-118 (1983).
P.E. Lindahl, On Counter Streaming Centrifugation in the Separation of Cells and Cell Fragments (1956), pp. 411-415.
C. Almici et al., Counterflow Centrifugal Elutriation: Present and Future, Bone Marrow Transplantation 1993, 12:105-108.
Richard J. Sanderson, Separation of Different Kinds of Nucleated Cells from Blood by Centrifugal Elutriation, Cell Separation Methods and Selected Applications, vol. 1, pp. 153-168. (undated).
P.C. Keng et al., Characterization of the Separation Properties of the Beckman Elutriator System, Cell Biophysics 3 (1981), pp. 41-56.
Biofil, Systems for Filtration of Haemocomponents. (undated).
Cl
Goodrich Raymond P.
Green Todd Curtis
Cobe Laboratories, Inc.
Kim John
LandOfFree
Method for using ligands in particle separation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for using ligands in particle separation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for using ligands in particle separation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1721511