Method for using division arrested cells in screening assays

Details Method for using division arrested cells in screening assays Method for using division arrested cells in screening assays

2011-06-14

2011-06-14

Mertz, Prema (Department: 1646)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S006120, C435S007950, C435S041000

Reexamination Certificate

active

07960101

ABSTRACT:
Division arrested cells are used in screening assays to determine the effect of a substance of interest on the cells. The division arrested cells can be used in drug screening assays, signal transduction assays, and are especially useful in large scale, high throughput assays.

REFERENCES:
patent: 5998136 (1999-12-01), Kamb
patent: 6875576 (2005-04-01), Carreras
patent: 6897067 (2005-05-01), Uhler
patent: 7045281 (2006-05-01), Livelli et al.
patent: 2001/0046497 (2001-11-01), Zhang
patent: 2008/0081327 (2008-04-01), Livelli et al.
patent: 2008/0248516 (2008-10-01), Livelli et al.
patent: WO-02/42447 (2002-05-01), None
patent: WO-02064092 (2002-08-01), None
patent: WO 2003/034803 (2003-05-01), None
Barak, Larry S., et al., “Real-time Visualization of the Cellular Redistribution of G Protein-coupled Receptor Kinase 2 and β-Arrestin 2 during Homologous Desensitization of the Substance P Receptor”, The Journal of Biological Chemistry, vol. 274, No. 11, pp. 7565-7569, Mar. 12, 1999.
Cho, G., et al., The transcriptional repression of the human Cu/Zn superoxide dismutase (sod1) gene by anticancer drug, mitomycin C(MMC), Biochem Mol Bio Int, 42(5):949-56, Aug. 1997.
Fueger, Barbara J., et al., “Effects of Chemotherapeutic Agents on Expression of Somatostatin Receptors in Pancreatic Tumor Cells”, The Journal of Nuclear Medicine, vol. 42, No. 12, pp. 1856-1862, Dec. 2001.
Goetz, AS, et al., Development of a facile method for high throughput screening with reporter gene assays, J Biomol Screen, 5(5): 377-84, Oct. 2000.
Hudson, James D., “A Proinflammatory Cytokine Inhibits p53 Tumor Suppressor Activity,” J. Exp. Med., vol. 190, No. 10, pp. 1375-1382, Nov. 15, 1999.
Kharbanda, Surender, et al., “Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents”, Nature, vol. 376:31, 785-788, Aug. 1995.
King, K., et al., “Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit”, Science, 250 (4977), pp. 121-123; Oct. 5, 1990.
Müller, Martina, et al., “p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs”, J. Exp. Med., vol. 188, No. 11, pp. 2033-2045, Dec. 7, 1998.
Mundell, Stuart J., et al., “Selective Regulation of Endogenous G Protein-coupled Receptors by Arrestins in HEK293 Cells”, The Journal of Biological Chemistry, vol. 275, No. 17, pp. 12900-12908, Apr. 2000.
Yao, Kang-Shen, et al., “Involvement of Activator Protein-1 and Nuclear Factor-κB Transcription Factors in the Control of the DT-Diaphorase Expression Inducted by Mitomycin C Treatment”, Molecular Pharmacology, vol. 51, pp. 422-430, 1997.
EP03751966, “European Search Report Mailed Nov. 2, 2006”, 3.

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