Chemistry: analytical and immunological testing – Peptide – protein or amino acid
Reexamination Certificate
2007-01-22
2009-12-01
Monshipouri, Maryam (Department: 1656)
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
C514S012200
Reexamination Certificate
active
07625759
ABSTRACT:
The present invention provides for a method of using BOC/CDO hedgehog antagonists to inhibit hedgehog signaling, as well as treating and diagnosing disorders relating to hedgehog signaling or overexpression of hedgehog, including cancer, cell proliferative disorders, and angiogenesis, neurological disorders, as well as other conditions affected by hedgehog signaling such as hair growth, neural stem cell differentiation, chondrogenesis and osteogenesis, lung surfactant production, formation of lamellated bodies in lung cells.
REFERENCES:
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 5229275 (1993-07-01), Goroff
patent: 5428130 (1995-06-01), Capon et al.
patent: 5545806 (1996-08-01), Lonberg et al.
patent: 5545807 (1996-08-01), Surani et al.
patent: 5565332 (1996-10-01), Hoogenboom et al.
patent: 5567610 (1996-10-01), Borrebaeck et al.
patent: 5569825 (1996-10-01), Lonberg et al.
patent: 5571894 (1996-11-01), Wels et al.
patent: 5573905 (1996-11-01), Lerner et al.
patent: 5587458 (1996-12-01), King et al.
patent: 5591669 (1997-01-01), Krimpenfort et al.
patent: 5641870 (1997-06-01), Rinderknecht et al.
patent: 2003/0064443 (2003-04-01), Baker et al.
patent: 2005/0085519 (2005-04-01), Rubin et al.
patent: 93/16185 (1993-08-01), None
patent: 95/18856 (1995-07-01), None
patent: 96/17924 (1996-06-01), None
patent: 02/30462 (2002-04-01), None
patent: 2006/132788 (2006-12-01), None
Apelqvist et al., “Sonic Hedgehog Directs Specialised Mesoderm Differentiation in the Intestine and Pancreas”Current Biology7(10):801-804 (Oct. 1, 1997).
Beck and D'Amore, “Vascular development: cellular and molecular regulation”FASEB J. 11(5):365-373 (Apr. 1997).
Bellusci et al., “Involvement of Sonic Hedgehog (Shh) in Mouse Embryonic Lung Growth and Morphogenesis”Development124(1) :53-63 (Jan. 1997).
Bitgood et al., “Sertoli Cell Signaling by Desert Hedgehog Regulates the Male Germline”Current Biology6(3):298-304 (Mar. 1, 1996).
Boring et al., “Cancer Statistics, 1993”CA Cancer J. Clin. 43(1):7-26 (Jan.-Feb. 1993).
Brennan et al., “Preparation of bispecific antibodies by chemical recombination of monoclonal immunoglobulin G1fragments”Science229(4708):81-83 (Jul. 5, 1985).
Bruggemann et al., “Designer Mice: The Production of Human Antibody Repertoires in Transgenic Animals”Year Immunol. 7:33-40 (1993).
Buschmann and Scaper, “The pathophysiology of the collateral circulation (arteriogenesis)”Journal of Pathology190(3):338-342 (Feb. 2000).
Carpenter et al., “Characterization of Two Patched Receptors for the Vertebrate Hedgehog Protein Family.”Proc. Natl. Acad. Sci. USA95(23):13630-13634 (Nov. 1998).
Carter et al., “High LevelEscherichia coliExpression and Production of a Bivalent Humanized Antibody Fragment”Bio/Technology10(2):163-167 (Feb. 1992).
Carter et al., “Humanization of an Anti-p185HER2Antibody For Human Cancer Therapy”Proc. Natl. Acad. Sci. USA89(10):4285-4289 (May 1992).
Cherrington et al., “New paradigms for the treatment of cancer: the role of anti-angiogenesis agents”Adv. Cancer Res. 79:1-38 (2000).
Chothia and Lesk, “Canonical Structures for the Hypervariable Regions of Immunoglobulins”J Mol Biol. 196(4):901-917 (Aug. 20, 1987).
Clackson et al., “Making Antibody Fragments Using Phage Display Libraries”Nature352 (6336):624-628 (Aug. 15, 1991).
Cole et al., “Microform holoprosencephaly in mice that lack the Ig superfamily member Cdon”Curr Biol. 13(5):411-415 (Mar. 4, 2003).
Echelard et al., “Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity”Cell75(7):1417-1430 (Dec.31, 1993).
Ericson et al., “Sonic hedgehog induces the differentiation signal for ventral forebrain neurons: a common signal for ventral patterning within the neural tube”Cell81(5):747-756 (Jun. 2, 1995).
Evan et al., “Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product”Molecular&Cellular Biology5(12):3610-3616 (Dec. 1985).
Fan and Tessier-Levigne, “Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog”Cell79(7):1175-1186 (Dec. 30, 1994).
Field et al., “Purification of a RAS-Responsive Adenylyl Cyclase Complex fromSaccharomyces cerevisiaeby Use of an Epitope Addition Method”Molecular&Cellular Biology8(5):2159-2165 (May 1988).
Folkman and Shing, “Angiogenesis”Biol Chem. 267(16):10931-10934 (Jun. 5, 1992).
Folkman, “Tumor angiogenesis”Adv Cancer Res. 43:175-203 (1985).
Griffiths et al., “Human anti-self antibodies with high specificity from phage display libraries”EMBO Journal12(2):725-734 (Feb 1993).
Hannon and Rossi, “Unlocking the potential of the human genome with RNA interference”Nature431(7006):371-378 (Sep. 16, 2004).
Ho et al., “Sonic hedgehog in the nervous system: functions, modifications and mechanisms”Curr. Opin. Neurobiol. 12(1) :57-63 (Feb. 2002).
Hopp et al., “A Short Polypeptide Marker Sequence Useful for Recombinant Protein Identification and Purification”Bio/Technology6:1204-1210 (1988).
Hynes et al., “Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1”Neuron. 19(1):15-26 (Jul. 1997).
Jakobovits at al., “Analysis of Homozygous Mutant Chimeric Mice: Deletion of the Immunoglobulin Heavy-Chain Joining Region Blocks B-cell Development and Antibody Production”Proc. Natl. Acad. Sci. USA90(6):2551-2555 (Mar. 15, 1993).
Jakobovits et al., “Germ-line Transmission and Expression of a Human-Derived Yeast Artificial Chromosome”Nature362(6417):255-258 (Mar. 18, 1993).
Jarov et al., “A dual role for Sonic hedgehog in regulating adhesion and differentiation of neuroepithelial cells”Dev. Biol. 261(2):520-536 (Sep. 15, 2003).
Johnson & Chiswell, “Human antibody engineering”Current Opinion in Structural Biology3:564-571 (1993).
Johnson et al., “Ectopic Expression of Sonic Hedgehog Alters Dorsal-Ventral Patterning or Somites”Cell79(7):1165-1173 (Dec. 30, 1994).
Jones et al., “Replacing the Complementarity-Determining Regions in a Human Antibody with Those From a Mouse”Nature321(6069) :522-525 (May 29, 1986).
Kang et al., “BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation”EMBO Journal21(1-2):114-124 (Jan. 15, 2002).
Kang et al., “CDO, a robo-related cell surface protein that mediates myogenic differentiation”J Cell Biol. 143(2) :403-413 (Oct 19, 1998).
Kang et al., “Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation”Proc Natl Acad Sci U S A100(7):3989-3994 (Apr. 1, 2003).
Klagsbrun and D'Amore, “Regulators of angiogenesis”Ann. Rev. Physiol. 53:217-239 (1991).
Kohler and Milstein, “Continuous.Cultures of Fused Cells Secreting Antibody of Predefined Specificity”Nature256(5517) :495-497 (Aug. 7, 1975).
Krauss et al., “A Functionally Conserved Homolog of theDrosophilaSegment Polarity Gene hh is Expressed in Tissues with Polarizing Activity in Zebrafish Embryos”Cell75(7):1431-1444 (Dec. 31, 1993).
Lum et al., “Identification of Hedgehog pathway components by RNAi inDrosophilacultured cells”Science299(5616) :2039-2045 (Mar. 28, 2003).
Lutz-Freyermuth et al., “Quantitative Determination That One of Two Potential RNA-binding Domains of the A Protein Component of the U1 Small Nuclear Ribonucleoprotein Complex Binds with High Affinity to Stem-loop II of U1 RNA”Proc. Natl. Acad. Sci. USA87:6393-6397 (Aug. 1990).
Marks et al., “By-Passing Immunization: Human Antibodies From V-gene Libraries Displayed On Phage”J. Mol. Biol. 222(3) :581-597
de Sauvage Frederic J.
Tian Hua
Farley Patrick J.
Genentech Inc.
Monshipouri Maryam
Svoboda Craig
LandOfFree
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