Method for using a photonic crystal fiber as a Raman biosensor

Details Method for using a photonic crystal fiber as a Raman biosensor Method for using a photonic crystal fiber as a Raman biosensor

2008-07-16

2010-06-15

Evans, F. L (Department: 2877)

Optics: measuring and testing

By dispersed light spectroscopy

With raman type light scattering

C385S125000

Reexamination Certificate

active

07738097

ABSTRACT:
A method is provided for biosensing using a photonic crystal fiber having a hollow core. The method includes: designating an analyte of interest; determining a wavelength for an excitation light source which generates a Raman spectrum when incident upon the analyte of interest; selecting a photonic crystal fiber that would guide the light when the fiber is non-selectively filled with a solvent hosting the analyte of interest; non-selectively filling a photonic crystal fiber with the solvent hosting the analyte of interest; interrogating the analyte of interest by coupling light from the light source to the photonic crystal fiber; and analyzing the light output from the photonic crystal fiber for Raman fingerprints.

REFERENCES:
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Yan et al., “Hollow core photonic crystal fiber surface-enhanced Raman probe”, Applied Physics Letters, 89, 204101, Nov. 15, 2006.
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G. Antonopoulos, et al. “Experimental demonstration of the frequency shift of bandgaps in photonic crystal fibers due to refractive index scaling.” Optics Express Apr. 3, 2006/vol. 14, No. 7.

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