Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1990-01-22
1992-03-10
Rosenbaum, C. Fred
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
128654, 1286534, 436806, 436173, G01N 3100, A61B 550
Patent
active
050948377
ABSTRACT:
Structural and functional imaging of the pancreas can be achieved with magnetic resonance imaging and a secretin solution. An amount of secretin is placed in solution and administered to a patient for the purpose of pancreatic imaging. Because the secretin solution changes the signal intensity of the pancreas, it can be imaged relative to baseline fasting studies for the purposes of tumor detection and qualification of exocrine dysfunction.
REFERENCES:
Schneider et al., NMR Spectrometric Stool Fat Analysis--A New Technique for Quantifying Steatorrhea and Establishing the Indication for Enzyme Replacement in Chronic Pancreatitis; Hepato-gastroenterol (1985), pp. 210-215.
Puolakkainen et al., Magnetic Resonance Imaging in Detecting Acute Oedematous and Haemorrhagic Pancreatitis: An Experimental Study in Pigs, 1989, Eur. Surg. Res., pp. 25-33.
Schneider et al., NMR Spectrometry, A New Method for Total Stool Fat Quantification in Chronic Pancreatitis, Digestive Diseases and Sciences (May 1987), pp. 494-499.
Mutt, V.: "Vasoactive Intestinal Polypeptide and Related Peptides"; Isolation and Chemistry Annals of the New York Academy of Sciences, 527, pp. 1-19; 1988.
Christope, J. et al: "Vasoactive Intestinal Peptide Receptors in Pancreas and Liver Structure--Function Relationship"; Annals of the New York Academy of Sciences, 527, pp. 238-256; 1988.
Van Dyke, J. et al: "Pancreatic Imaging"; Annals of Internal Medicine, 102, pp. 212-217; 1985.
Niederau, C. et al: "Diagnosis of Chronic Pancreatitis"; Gastroenterology, 88, pp. 1973-1995; 1985.
Carlquist, M. et al: "Isolation and Amino Acid Sequence of Bovine Secretin"; FEBS Letters, 127, No. 1, pp. 71-74; 1981.
Bis, K. G. et al: "Clinical Applications of Magnetic Resonance (MR) Contrast Agents"; ACS, University of Kansas; Nov. 6, 1989.
Polutta Mark O.
Rosenbaum C. Fred
Wayne State University
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